In silico drug discovery of IKK-β inhibitors from 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives based on QSAR, docking, molecular dynamics and …
NEH Hammoudi, Y Benguerba, A Attoui… - Journal of …, 2022 - Taylor & Francis
The Inhibitor of IKK-β (nuclear factor kappa B kinase subunit beta), a specific modulator of
NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for
various cancers and rheumatoid arthritis treatment. In this study a series of thirty 2-amino-3-
cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives was involved for a quantitative
structure activity relationship model (QSAR) elaboration which allows the prediction of the
pIC50 values of new designed compounds. The model can be used to predict the activity of …
NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for
various cancers and rheumatoid arthritis treatment. In this study a series of thirty 2-amino-3-
cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives was involved for a quantitative
structure activity relationship model (QSAR) elaboration which allows the prediction of the
pIC50 values of new designed compounds. The model can be used to predict the activity of …
[引用][C] In silico drug discovery of IKK-β inhibitors from 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives based on QSAR, docking, molecular dynamics …
DY Nour-El-Houda Hammoudi, DAA Benguerba… - 2020 - dspace.univ-temouchent.edu.dz
The Inhibitor of IKK-β (nuclear factor kappa B kinase subunit beta), a specific modulator of
NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for
various cancers and rheumatoid arthritis treatment. In this study a series of thirty 2-amino-3-
cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives was involved for a quantitative
structure activity relationship model (QSAR) elaboration which allows the prediction of the
pIC50 values of new designed compounds. The model can be used to predict the activity of …
NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for
various cancers and rheumatoid arthritis treatment. In this study a series of thirty 2-amino-3-
cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives was involved for a quantitative
structure activity relationship model (QSAR) elaboration which allows the prediction of the
pIC50 values of new designed compounds. The model can be used to predict the activity of …
以上显示的是最相近的搜索结果。 查看全部搜索结果