Epigenetics regulation of prostate cancer: Biomarker and therapeutic potential

R Ragavi, P Muthukumaran, S Nandagopal… - … Oncology: Seminars and …, 2023 - Elsevier
… tool to discover novel potential biomarkers and drug targets. As per … Below we describe
individual genes identified as prognostic … methylation of IGFBP3 in CaP and highgrade prostate

A modern era of personalized medicine in the diagnosis, prognosis, and treatment of prostate cancer

VK Lakshmanan, S Ojha, Y Do Jung - Computers in Biology and Medicine, 2020 - Elsevier
… NGS is used to identify the novel gene mutations, insertions and deletions (InDels), copy
number variations (CNV), structural variations, and epigenetic alterations with high precision …

Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical …

D Feng, J Wang, D Li, R Wu, W Wei, C Zhang - Discover Oncology, 2023 - Springer
… , we used VGF, IGFBP3 and ANG to establish detrimental and … risk subtypes and risk scores,
we identified BCR-free survival-… of PCa through methylation [82]. These findings suggest that …

epiCaPture: a urine DNA methylation test for early detection of aggressive prostate cancer

E O'Reilly, AV Tuzova, AL Walsh, NM Russell… - JCO precision …, 2019 - ascopubs.org
… used to triage patients and identify those who actually require an invasive prostate biopsy to
… Complying with REMARK guidelines, we describe a new DNA methylation-based urine test …

Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Q Zeng, M Mousa, AS Nadukkandy, L Franssens… - … Reviews Cancer, 2023 - nature.com
… , PLVAP and IGFBP3) can be identified. Besides angiogenesis, … a novel anticancer therapeutic
approach. Therefore, we also discuss progress, limitations, solutions and novel targets for …

[HTML][HTML] Screening a novel six critical gene-based system of diagnostic and prognostic biomarkers in prostate adenocarcinoma patients with different clinical variables

H Munir, F Ahmad, S Ullah, SM Almutairi… - American Journal of …, 2022 - ncbi.nlm.nih.gov
… In the current study, we identified by microarray technology … other data (promoter methylation
status, genetic alterations, … AND Prostate cancer/adenocarcinoma” and “Hub genes AND …

The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells

D Dixit, BC Prager, RC Gimple, HX Poh, Y Wang, Q Wu… - Cancer discovery, 2021 - AACR
… We identified IGFBP3 as a downstream effector of the … –MYC–IGFBP3 axis as a specific
and novel therapeutic target in … transcriptome-wide m6A methylation analyses in two patient-…

Application of proteogenomics to urine analysis towards the identification of novel biomarkers of prostate cancer: an exploratory study

T Lima, AS Barros, F Trindade, R Ferreira… - Cancers, 2022 - mdpi.com
new protein targets for detecting PCa using a proteomics and proteogenomics approach. This
work identified … on comparing and mining the proteome profile of tumor prostate tissue and …

[HTML][HTML] Methylation biomarkers for early cancer detection and diagnosis: Current and future perspectives

J Ibrahim, M Peeters, G Van Camp… - … Journal of Cancer, 2023 - Elsevier
identify 759 CpG sites, including 15 located at novel loci, showing an association between
DNA methylation and prostate cancer … whose methylation status could identify cancer samples …

Aberrant expression of lncRNAs SNHG6, TRPM2‐AS1, MIR4435‐2HG, and hypomethylation of TRPM2‐AS1 promoter in colorectal cancer

T Ghasemi, M Khalaj‐Kondori… - Cell Biology …, 2021 - Wiley Online Library
… factor-binding protein 3 (IGFBP3), the eyes absent homolog 4 (… their mRNA targets existed
among the identified mRNAs for … reports in prostate cancer and non–small cell lung cancer. …