… of poorly water-soluble drugs. However, construction of in vitro and in vivo correlations (…
The lipophilic products of the breakdown of dietary fats (fatty acids and monoglycerides), as …

… was observed to assess whether diffusion in an unstirred water layer (UWL) or in a lipophilic
… The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal …

… water-soluble drugs, protect the drug from degradation in the … vitro and in vivo correlation
in order to justify the use of an in … Fenofibrate is a lipophilic drug used to treat abnormal lipid …

… II/IV drugs, such as naproxen, phenytoin, and diazepam, have an absolute bioavailability
(F) > 90%.6, 7 Second, although poorly water-soluble, lipophilic … in vitro–in vivo correlation. …

… The more water-soluble nicotine, only tested in the ex vivo … For more lipophilic FP (Flixotide,
MDI) the correlation of … between the ex vivo rat IPL and all three in vitro test models. The …

… they have defined relate to poorly water-soluble drugs, namely the … of poorly water-soluble
drugs), and the food-drug interface, which is crucial in consideration of the often lipophilic …

… In vitro – in vivo correlation (IVIVC) allows prediction of the in vivo performance of a
pharmaceutical product based on its in vitro drug release profiles and can be used to optimize …

… The self-emulsifying formulations were prepared using different natural/semi synthetic oils,
lipophilic/hydrophilic surfactants and water-soluble cosolvents. Different types of excipients …

… In this study, we have incorporated in vitro lipolysis with microsomal stability to
quantitatively predict the oral bioavailability of a lipophilic antineoplastic drug bexarotene (BEX) …

… Statins are well tolerated and exhibit minimum short term and long term side effects. Lovastatin
(LOV), a highly lipophilic drug is frequently used as a blood cholesterol-lowering agent. …