Preliminar evaluation of epigenetic modifications followingi vitro hydroquinone exposure in models of human acute promyelocytic leukemia cells (HL-60) and of …
M Mandruzzato - 2019 - irinsubria.uninsubria.it
… the epigenetic effects of the administration of low (non-cytotoxic) concentrations of … mark
was enriched in the promoters of several DNA damage responsive (DDR) genes including CRY1…
was enriched in the promoters of several DNA damage responsive (DDR) genes including CRY1…
Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway
… toxic effects (4). Benzene metabolites, including hydroquinone, can induce DNA damage
and … DSBs (5), one of the most cytotoxic forms of DNA damage (17). DSBs can be repaired by …
and … DSBs (5), one of the most cytotoxic forms of DNA damage (17). DSBs can be repaired by …
Ligand-independent activation of AhR by hydroquinone mediates benzene-induced hematopoietic toxicity
X Yang, C Li, G Yu, L Sun, S Guo, L Sai, C Bo… - Chemico-biological …, 2022 - Elsevier
… hydroquinone (HQ) and its role in HQ-induced DNA damage and apoptosis in cultured human
lymphocytes (JHP cells). We also investigated the effect … investigated the cytotoxicity of HQ …
lymphocytes (JHP cells). We also investigated the effect … investigated the cytotoxicity of HQ …
Clastogenicity and aneugenicity of 1, 4-benzoquinone in different lineages of mouse hematopoietic stem/progenitor cells
PW Chow, Z Abd Hamid, RD Mathialagan, NF Rajab… - Toxics, 2021 - mdpi.com
… Cytogenetic analysis was conducted using a method … Thus, both ranges of concentrations
(cytotoxic and non-cytotoxic) … by 1,4-BQ caused the DNA damage at the part of the telomere …
(cytotoxic and non-cytotoxic) … by 1,4-BQ caused the DNA damage at the part of the telomere …
Poly (ADP-ribose) polymerase-1 promotes expression of miR-155 by the up-regulation of methyl-CpG binding domain protein 2 in TK6 cells exposed to hydroquinone
Z Gui, H Zhang, Q Tan, X Ling, Z Liu, J Peng, J Shao… - Toxicology in vitro, 2019 - Elsevier
… MBD2, not by the classic role of PARP-1 which primarily involves DNA damage response. …
the result of DNA damage. We speculate that ROS-mediated cellular DNA damage may play …
the result of DNA damage. We speculate that ROS-mediated cellular DNA damage may play …
LINC00173 interacts with DNMT1 to regulate LINC00173 expression via promoter methylation in hydroquinone-induced malignantly transformed TK6 cells and …
H Zhang, Z Pan, X Ling, Q Tan, Q Yuan… - Toxicological …, 2022 - academic.oup.com
Long-term exposure to benzene or its metabolite, hydroquinone (HQ), can causally contribute
to acute myeloid leukemia. Long-noncoding RNAs are essential epigenetic regulators with …
to acute myeloid leukemia. Long-noncoding RNAs are essential epigenetic regulators with …
Validation of the γH2AX biomarker for genotoxicity assessment: a review
B Kopp, L Khoury, M Audebert - Archives of toxicology, 2019 - Springer
… DNA damage response (DDR) and plays a central role in sensing and repairing DNA
damage… using numerous methods in in vitro and in vivo experiments has been an attractive …
damage… using numerous methods in in vitro and in vivo experiments has been an attractive …
Dynamically monitoring cellular γ-H2AX reveals the potential of carcinogenicity evaluation for genotoxic compounds
M Qu, H Xu, W Li, J Chen, Y Zhang, B Xu, Z Li… - Archives of …, 2021 - Springer
… cytotoxic agents, often display positive results in cytogenetic … the relevant aspects of both
DNA damage potential and repair … , only CdCl 2 and hydroquinone were genotoxic in our assay…
DNA damage potential and repair … , only CdCl 2 and hydroquinone were genotoxic in our assay…
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia …
CH Yu, SQ Yang, L Li, Y Xin, F Zhang, XF Liu… - BMC Pharmacology and …, 2022 - Springer
… Hydroquinone (HQ) is a phenolic metabolite of benzene … leukemia by oxidative stress, DNA
damage, cell cycle regulation… to correspond to no obvious cytotoxicity but markedly inhibiting …
damage, cell cycle regulation… to correspond to no obvious cytotoxicity but markedly inhibiting …
In vitro and in vivo evaluation of genotoxicity, cytotoxicity, and protective effects of synthetic chalcones (E)-3-(4-chlorophenyl)-1-phenyl-2-propen-1-one (4-CL) and (E) …
EB Nunes, PZ Melo, J Barbosa, JH Veras… - … of Pharmaceutical and …, 2021 - syncsci.com
… cytotoxicity, genotoxicity and mutagenicity of 4-CL and DMF, and their protective effects against
DNA damage … with other compounds, such as hydroquinone, taxol, chloramphenicol and …
DNA damage … with other compounds, such as hydroquinone, taxol, chloramphenicol and …