… as compared to the lenalidomide-bortezomib combination [21]. … the combination of perifosine
with bortezomib blocks AKT … synergistic to bortezomib [161,162], antimyeloma activity has …

… with bortezomib, lenalidomide, or other novel agents in multiple myeloma (MM) cells in … or
in combination with novel drugs showed significant anti-myeloma effects on MM cells in vitro, …

… dose-dependent cytotoxicity in Doxorubicin-resistant, Lenalidomide-resistant and Bortezomib-…
The subsequent in-vitro study showed that although significant anti-myeloma effects were …

… perifosine in combination with lenalidomide and dexamethasone [Citation93], or bortezomib
… in RRMM was well tolerated and demonstrated some antimyeloma activity [Citation144] ( …

… studies, perifosine, an AKT inhibitor, was cytotoxic to MM … the effects of other anti-myeloma
drugs, particularly PI. … in combination with lenalidomide. Br J Haematol 2014;166:401-9. 190. …

… anti-myeloma agents. It is still early to assess whether these … evaluated the combination of
perifosine with bortezomib and … and 27% discontinued lenalidomide due to toxicity which was …

… drugs such as proteasome inhibitors (eg, bortezomib and carfizomib), immunomodulatory
drugs (eg, thalidomide and lenalidomide)… as a potent anti-myeloma agent in vitro and in animal …

… perifosine and might be at least partly due to lenalidomide [79]. Another phase I/II-trial testing
perifosine in combination with bortezomib … Potent in vitro anti-myeloma activity was induced …

… dependent cytotoxicity in Doxorubicinresistant, Lenalidomide… -vitro study showed that although
significant anti-myeloma effects … with perifosine against Akt. J Hematol Oncol. 2013;6:18. …

… immunomodulatory drugs (IMiDs) such as lenalidomide or … inhibiting activity displayed
promising anti-myeloma activity [80]. … perifosine combined with BTZ revealed increase cytotoxicity …