Asymmetric assembly of centromeres epigenetically regulates stem cell fate
AA Dattoli, BL Carty, AM Kochendoerfer… - Journal of Cell …, 2020 - rupress.org
… Our work shows that centromere assembly epigenetically drives … centromeres crucial for
cell division, while the asymmetric distribution of CID sister chromatids regulates asymmetric cell …
cell division, while the asymmetric distribution of CID sister chromatids regulates asymmetric cell …
Asymmetric centromeres differentially coordinate with mitotic machinery to ensure biased sister chromatid segregation in germline stem cells
… Second, temporally asymmetric microtubule activities … asymmetric sister kinetochores and
sister centromeres. Abolishment of either the asymmetric sister centromeres or the asymmetric …
sister centromeres. Abolishment of either the asymmetric sister centromeres or the asymmetric …
Centromere function in asymmetric cell division in Drosophila female and male germline stem cells
AM Kochendoerfer, F Modafferi… - Open …, 2021 - royalsocietypublishing.org
… -C have demonstrated important roles not only in asymmetric centromere assembly in GSCs
but … The future stem cell side (left) shows a higher amount of centromeric proteins CID (red), …
but … The future stem cell side (left) shows a higher amount of centromeric proteins CID (red), …
Centromere proteins are asymmetrically distributed between newly divided germline stem and daughter cells and maintain a balanced niche in Drosophila males
AM Kochendoerfer, RS Keegan… - Molecular Biology of the …, 2023 - Am Soc Cell Biol
… White dashed line highlights a GSC and GB pair in S phase; zoom shows CID foci in …
to these essential genes. As a complementary means to disrupt centromere asymmetry in …
to these essential genes. As a complementary means to disrupt centromere asymmetry in …
CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells
BL Carty, AA Dattoli, EM Dunleavy - PLoS Genetics, 2021 - journals.plos.org
… centromeres plays an important role in determining cell fate upon asymmetric division occurring
in stem … female germ line stem cells (GSCs) that CID assembly shows unique properties […
in stem … female germ line stem cells (GSCs) that CID assembly shows unique properties […
Asymmetric distribution of centromere proteins between germline stem and daughter cells maintains a balanced niche in Drosophila males
AM Kochendoerfer, EM Dunleavy - bioRxiv, 2022 - biorxiv.org
… White dashed line highlights a GSC and GB pair in S-phase; zoom shows CAL1 foci in … to
these essential genes. As a complementary means to disrupt centromere asymmetry in GSCs, …
these essential genes. As a complementary means to disrupt centromere asymmetry in GSCs, …
Centromere assembly and non-random sister chromatid segregation in stem cells
BL Carty, EM Dunleavy - Essays in Biochemistry, 2020 - portlandpress.com
… evidence for asymmetric sister centromeres in stem cells. … The asymmetric nature of a stem
cell is fundamental to the … ] to human cell LacO arrays reveals an epigenetic loop of assembly …
cell is fundamental to the … ] to human cell LacO arrays reveals an epigenetic loop of assembly …
CENP-A drives asymmetric cell division and maintains stem identity
AA Dattoli, BL Carty, AM Kochendoerfer, AE Walshe… - bioRxiv, 2019 - biorxiv.org
… In summary, our cell cycle analysis of centromere … From our analysis we can conclude that
CAL1 is crucial for stem … This analysis reveals that GSCs initiate CID incorporation during G2 …
CAL1 is crucial for stem … This analysis reveals that GSCs initiate CID incorporation during G2 …
Asymmetric histone inheritance in asymmetrically dividing stem cells
… Histone proteins represent crucial epigenetic components … fork shows a high percentage
of unidirectional or asymmetric … , such as sister centromeres, as well as asymmetries in trans-…
of unidirectional or asymmetric … , such as sister centromeres, as well as asymmetries in trans-…
Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells
EH Zion, C Chandrasekhara, X Chen - Current opinion in cell biology, 2020 - Elsevier
… chromatids have asymmetric levels of centromere protein in male Drosophila germline … In
vivo analysis of centromeric proteins reveals a stem cell-specific asymmetry and an essential …
vivo analysis of centromeric proteins reveals a stem cell-specific asymmetry and an essential …