Asymmetric assembly of centromeres epigenetically regulates stem cell fate

AA Dattoli, BL Carty, AM Kochendoerfer… - Journal of Cell …, 2020 - rupress.org
… Our work shows that centromere assembly epigenetically drives … centromeres crucial for
cell division, while the asymmetric distribution of CID sister chromatids regulates asymmetric cell …

Asymmetric centromeres differentially coordinate with mitotic machinery to ensure biased sister chromatid segregation in germline stem cells

R Ranjan, J Snedeker, X Chen - Cell stem cell, 2019 - cell.com
… Second, temporally asymmetric microtubule activities … asymmetric sister kinetochores and
sister centromeres. Abolishment of either the asymmetric sister centromeres or the asymmetric

Centromere function in asymmetric cell division in Drosophila female and male germline stem cells

AM Kochendoerfer, F Modafferi… - Open …, 2021 - royalsocietypublishing.org
… -C have demonstrated important roles not only in asymmetric centromere assembly in GSCs
but … The future stem cell side (left) shows a higher amount of centromeric proteins CID (red), …

Centromere proteins are asymmetrically distributed between newly divided germline stem and daughter cells and maintain a balanced niche in Drosophila males

AM Kochendoerfer, RS Keegan… - Molecular Biology of the …, 2023 - Am Soc Cell Biol
… White dashed line highlights a GSC and GB pair in S phase; zoom shows CID foci in …
to these essential genes. As a complementary means to disrupt centromere asymmetry in …

CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells

BL Carty, AA Dattoli, EM Dunleavy - PLoS Genetics, 2021 - journals.plos.org
centromeres plays an important role in determining cell fate upon asymmetric division occurring
in stem … female germ line stem cells (GSCs) that CID assembly shows unique properties […

Asymmetric distribution of centromere proteins between germline stem and daughter cells maintains a balanced niche in Drosophila males

AM Kochendoerfer, EM Dunleavy - bioRxiv, 2022 - biorxiv.org
… White dashed line highlights a GSC and GB pair in S-phase; zoom shows CAL1 foci in … to
these essential genes. As a complementary means to disrupt centromere asymmetry in GSCs, …

Centromere assembly and non-random sister chromatid segregation in stem cells

BL Carty, EM Dunleavy - Essays in Biochemistry, 2020 - portlandpress.com
… evidence for asymmetric sister centromeres in stem cells. … The asymmetric nature of a stem
cell is fundamental to the … ] to human cell LacO arrays reveals an epigenetic loop of assembly …

CENP-A drives asymmetric cell division and maintains stem identity

AA Dattoli, BL Carty, AM Kochendoerfer, AE Walshe… - bioRxiv, 2019 - biorxiv.org
… In summary, our cell cycle analysis of centromere … From our analysis we can conclude that
CAL1 is crucial for stem … This analysis reveals that GSCs initiate CID incorporation during G2 …

Asymmetric histone inheritance in asymmetrically dividing stem cells

M Wooten, R Ranjan, X Chen - Trends in Genetics, 2020 - cell.com
… Histone proteins represent crucial epigenetic components … fork shows a high percentage
of unidirectional or asymmetric … , such as sister centromeres, as well as asymmetries in trans-…

Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells

EH Zion, C Chandrasekhara, X Chen - Current opinion in cell biology, 2020 - Elsevier
… chromatids have asymmetric levels of centromere protein in male Drosophila germline … In
vivo analysis of centromeric proteins reveals a stem cell-specific asymmetry and an essential