Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment
W Liao, C Liu, K Yang, J Chen, Y Wu, S Zhang… - Cellular & Molecular …, 2023 - nature.com
… of BM Tregs during HSC aging. Thus, Tregs seem to be versatile in the stem cell niche, beyond
… Identifying targets specific to stem cell–Treg interactions will provide superior therapeutic …
… Identifying targets specific to stem cell–Treg interactions will provide superior therapeutic …
[HTML][HTML] Leukocyte trafficking and regulation of murine hematopoietic stem cells and their niches
D Lucas - Frontiers in Immunology, 2019 - frontiersin.org
… capable of giving rise to all other types of hematopoietic cells found … were surrounded by
Foxp3 + regulatory T cells. Depletion of … that Tregs confer immune privilege to the niche via IL10 …
Foxp3 + regulatory T cells. Depletion of … that Tregs confer immune privilege to the niche via IL10 …
[HTML][HTML] Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis
L Fischer, C Herkner, R Kitte, S Dohnke… - Frontiers in …, 2019 - frontiersin.org
… niche-associated Treg cells contribute to the maintenance of the BM microenvironment as an
immune privilege … Figure 4), providing first direct evidence that Treg cells can remove CD80/…
immune privilege … Figure 4), providing first direct evidence that Treg cells can remove CD80/…
[HTML][HTML] Paradoxical regulation of allogeneic bone marrow engraftment and immune privilege by mesenchymal cells and adenosine
M Kakiuchi, Y Hirata, SC Robson, J Fujisaki - Transplantation and cellular …, 2021 - Elsevier
… -residential regulatory T cells (Tregs), which promote … Although other tissue-committed
stem cell niches have not been … Lepr-cre mice were kindly provided by Lei Ding. CD39-flox …
stem cell niches have not been … Lepr-cre mice were kindly provided by Lei Ding. CD39-flox …
[HTML][HTML] BATF sustains homeostasis and functionality of bone marrow Treg cells to preserve homeostatic regulation of hematopoiesis and development of B cells
… Bone marrow Treg cells (BM Tregs) orchestrate stem cell niches crucial for hematopoiesis. …
Collectively, our studies provide mechanistic insights underlying Treg-dependent regulation …
Collectively, our studies provide mechanistic insights underlying Treg-dependent regulation …
[HTML][HTML] Hematopoietic stem cell niche during homeostasis, malignancy, and bone marrow transplantation
Y Man, X Yao, T Yang, Y Wang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
… Single-cell sequencing and in vivo imaging are powerful … We believe that this comprehensive
review will provide clues for … Regulatory T cells (Tregs) play a vital role in building …
review will provide clues for … Regulatory T cells (Tregs) play a vital role in building …
Immune privilege of skin stem cells: What do we know and what can we learn?
J Agudo - Experimental Dermatology, 2021 - Wiley Online Library
… other αβ T cells such as CD4 + T cells and regulatory T cells (T… fibrosis, further impairing the
stem cell niche. Disruption of the … immune pressure trying to provide immune evasion to stem …
stem cell niche. Disruption of the … immune pressure trying to provide immune evasion to stem …
[HTML][HTML] Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells
M Hinterbrandner, V Rubino, C Stoll, S Forster… - JCI insight, 2021 - ncbi.nlm.nih.gov
… leukemia patients receiving allogenic hematopoietic stem cell transplantation (aHSCT… Tregs
are an important regulator of homeostasis in the BM and provide an immune privilege niche …
are an important regulator of homeostasis in the BM and provide an immune privilege niche …
[HTML][HTML] Tissue Treg secretomes and transcription factors shared with stem cells contribute to a Treg niche to maintain Treg-ness with 80% innate immune pathways …
… have provided novel insights on the roles of innate immune … a stem cell niche-like
microenvironment for Treg maintenance. … of regulatory T cells (Treg) versus conventional T cells …
microenvironment for Treg maintenance. … of regulatory T cells (Treg) versus conventional T cells …
[HTML][HTML] Transient regulatory T-cell targeting triggers immune control of multiple myeloma and prevents disease progression
J Dahlhoff, H Manz, T Steinfatt, J Delgado-Tascon… - Leukemia, 2022 - nature.com
… regulatory T cells (Tregs) are highly abundant amongst CD4 + T cells providing an immune
protective niche for different long-living cell populations, eg, hematopoietic stem cells. Here, …
protective niche for different long-living cell populations, eg, hematopoietic stem cells. Here, …