… Examining how these mutations have spread through the … of drug, by combining data from
in vivo screening, genetic interactions, … However, because only 50% of azole-resistant clinical …

… to cause ECR and echinocandin therapeutic failure in vivo [Citation11]. HS … azole-resistant
Candida spp., including C. auris. Cross-resistance with other echinocandins to FKS mutations …

… mutations in the transcription factors regulating ergosterol biosynthesis.18–21 Overexpression
of ERG11 has also been identified in azole-resistant isolates of C… in vivo activity against C. …

… A mutation in hapE was initially found in an azole-resistant clinical … glabrata, resistance
can be conferred by mutations in either … reduce fitness in vivo [139]. In total, 43.75% (7/16) of …

… We discover that mutation of genes encoding the Ubr2/Mub1 … Second, we sought to confirm
the interaction in vivo by co-… resistance in Candida glabrata and fluconazole tolerance in C. …

… asahii azole-resistant strains found several genes differentially expressed and highly mutated,
… As a consequence, clinical management is highly dependent on in vitro and in vivo data …

… heritable genetic mutations, and all mutant progeny exhibits … Iron starvation also increased
azole susceptibility in vivo in a … Interestingly, azole-resistant Candida auris have higher chitin …

… is the organization of cell communities in vivo. For instance, treatment can … of negative selection
imposed by the 5-FU-producing FUR1 mutants. … glabrata in response to fluconazole [47]. …

… , with synergy also against azole-resistant isolates and biofilms. Further … Initially, a rho 0
mutant was tested to assess whether the loss … could be quite different in vivo or with synergistic …

… In vivo resistance develops in individuals during antifungal … The pathogenic fungi Candida
glabrata and Candida albicans … Documentation of new ERG11 mutations in azole-resistant …