… presenilin 1–N-methyl-d-aspartate receptor complexes differs from that of wild type complexes
and neurons of mutant-expressing brains are more vulnerable to … a novel presenilin 1-…

… is also affected by presenilin-1 alterations. Mutations in PSEN1 enhanced InsP3R gating,
elevating … [72, 73, 84, 85], and in the long term it can lead to excitotoxicity and cell death [48]. A …

… mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2)
genes. AD mutations … More than 150 autosomal dominant mutations in PS1 and 14 in …

… secretase comprises the aspartyl protease presenilin 1/2 (PS1/… neuronal vulnerability to
excitotoxicity can be enhanced by … and in mutant APP transgenic mice express higher levels of …

… to increased neuronal activity and vasodilatory mediators, such as bradykinin and acetylcholine,
are diminished in APP mutant … in neurons can protect them against excitotoxic and …

… frame 72 mutations appear to have increased vulnerability to … cell metabolism due to
misfolded mutant SOD1 deposits in … of mutant SOD1 in mitochondria can lead to an increase of …

… in three genes - amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (…
mutations primarily aimed to identify neuronal cell types that displayed greater vulnerability …

… receptor, which is a member of the tumor necrosis factor receptor superfamily [59,65]… mutant
APP [19,141]. Morphological and functional alterations similar to those elicited by excitotoxic …

… and hippocampal networks, with subsequent excitotoxicity … wild type presenilin 1 (PS1wt)
and APPswe mutations through … of IL-1β, tumour necrosis factor alpha (TNFα), and interleukin …

… ) hyperactivation contributes to excitotoxicity in patients with AD. … )ergic APP/presenilin-1
(PS1) processing primary neurons. As … Mutations in APP and PS1 lead to elevated secretion of …