[HTML][HTML] … analysis elucidates the enhanced skeletal muscle mass, reduced fat accumulation, and metabolically benign liver in human follistatin-344 transgenic pigs
K Long, XK Li, R Zhang, YR Gu, MJ Du, XY Xing… - Journal of Integrative …, 2022 - Elsevier
… a dramatic increase of muscle mass and involve … muscle or repeated subcutaneous
injections of FST mRNA-loaded nanoparticles induced significant decrease of fat content in mice (…
injections of FST mRNA-loaded nanoparticles induced significant decrease of fat content in mice (…
Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression
… the first liposomal mRNA vaccine was tested in mice, highlighting … in very effective mRNA
delivery to the liver, leading to the … increasing two-fold the extent of mRNA delivery to the liver. …
delivery to the liver, leading to the … increasing two-fold the extent of mRNA delivery to the liver. …
Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD
… delivery, and we rationalized that immunocompromised mice would … in the spleen and
liver by threefold and 1.5-fold in mdx mice, … muscle, in a similar manner to nanoparticle-mediated …
liver by threefold and 1.5-fold in mdx mice, … muscle, in a similar manner to nanoparticle-mediated …
New intranasal and injectable gene therapy for healthy life extension
DK Jaijyan, A Selariu, R Cruz-Cosme… - Proceedings of the …, 2022 - National Acad Sciences
… follistatin expression in aged mice not only increased muscle … analysis of TERT and FST
mRNAs and proteins in blood and … , kidney, liver, lung, and skeletal muscle from MCMV TERT or …
mRNAs and proteins in blood and … , kidney, liver, lung, and skeletal muscle from MCMV TERT or …
Nanoparticles targeting the molecular pathways of heart remodeling and regeneration
… nm tend to accumulate into the liver and lung, the ones smaller … to powder aliskiren and even
increased nitric oxide synthase (… in mice Delivery of VEGF-A enhanced angiogenesis, while …
increased nitric oxide synthase (… in mice Delivery of VEGF-A enhanced angiogenesis, while …
Overcoming nature's paradox in skeletal muscle to optimise animal production
GS Lynch, R Koopman - Animal Production Science, 2019 - CSIRO Publishing
… Using viral vectors to force expression of follistatin in mouse … virus follistatin delivery,
nanoparticle-mediated delivery of … vector methods and nanoparticle-mediated delivery of mRNA …
nanoparticle-mediated delivery of … vector methods and nanoparticle-mediated delivery of mRNA …
[PDF][PDF] Nanoparticles Targeting the Molecular Pathways of Heart Remodeling and Regeneration. Pharmaceutics 2022, 14, 711
… nm tend to accumulate into the liver and lung, the ones smaller … infarction by left anterior
descending artery ligation in rats … At day 3, the expression level of AT1 mRNA was significantly …
descending artery ligation in rats … At day 3, the expression level of AT1 mRNA was significantly …
Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances
… mRNA levels in aged skeletal muscle, with remarkably similar … redox homeostasis in the
aged skeletal muscle of mice. … in skeletal muscle strength and plasma levels of follistatin and …
aged skeletal muscle of mice. … in skeletal muscle strength and plasma levels of follistatin and …
Poly (aspartic acid)-Based polymeric nanoparticle for local and systemic mRNA delivery
… It requires delivery systems that improve the stability of mRNA in … In vivo studies in mice
revealed that PNP with optimal … various organs including the liver, but the mRNA was exclusively …
revealed that PNP with optimal … various organs including the liver, but the mRNA was exclusively …
mRNA, a revolution in biomedicine
… at certain organs, such as liver, lungs and heart, mainly … LNP in order to treat a Factor IX
(FIX)-deficient mouse as a … regeneration by upregulating mutated human follistatin-like protein 1 (…
(FIX)-deficient mouse as a … regeneration by upregulating mutated human follistatin-like protein 1 (…