… [Shh], Desert hedgehog [Dhh], and Indian hedgehog [Ihh]) … that Shh promotes γδ T-cell
development in the thymus and … Hh pathway activation signals to promote maturation, both by …

… , cell proliferation, and differentiation 6 . Vertebrate Hh signaling … This crucial role for
Gli3 seems to be restricted to CD4 + T … N-terminal active fragment of Indian Hedgehog (Bio-Techne, …

… , Ihh−/−, Gli2ΔN2-transgenic and Gli2ΔC2-transgenic thymi (30,36,38). Gli1 was shown to
promote the differentiation of DN thymocytes … Introduction of a class I-restricted transgenic TCR …

… developing T cells into MHC-restricted self-antigen tolerant T … Sonic Hedgehog (Shh),
Indian Hedgehog (Ihh), and Desert … anti-CD3mAb promoted thymocyte differentiation to the DP …

… A previous publication [35] has shown that Ihh produced by developing thymocytes both
promotes and restricts thymocyte differentiation. However, SEB-treatment does not affect Ihh …

… necrosis factor (TNF) promoted Gli1 + cell proliferation and … , NF-κB, and Hedgehog signaling
through Gli1 + cells in both organs (… Given the tissue-restricted expression of Ihh, it may be …

… in T cell development in the thymus 8. Given the structural and … Ihh N-peptide were unable
to promote Th17 differentiation in … This crucial role for Gli3 seems to be restricted to CD4+ T …

… change in Dhh and Ihh transcripts (Figure 1B). Ptch1 and Gli1, which are both Hh pathway
… donors (Figure 8F), suggesting that Shh can promote Treg differentiation in human T cells. …

… points: Hedgehog ligand Sonic Hedgehog (Shh) promotes … role of Hedgehog in physiological
Th2 differentiation remains to … own endogenous Hedgehog ligand, Indian Hedgehog (Ihh). …

… Sonic hedgehog (Shh), but not Dhh and Ihh, exhibits a … by airway epithelium encourages
the Th2 differentiation of CD4 … , and hence may possibly restrict the EBV detection through the …