Hypoxia-inducible factors and innate immunity in liver cancer

VWH Yuen, CCL Wong - The Journal of clinical …, 2020 - Am Soc Clin Investig
… VEGF also activates VEGFR1 (also known as FLT-1) on monocytes and … Hypoxia
induces VEGF expression in human HCC cell lines by activating VEGF gene transcription and …

[HTML][HTML] Hypoxia‑inducible factors in hepatocellular carcinoma

Y Guo, Z Xiao, L Yang, Y Gao… - Oncology …, 2020 - build.spandidos-publications.com
… as crucial transcriptional regulators that are activated under hypoxia (2). A … certain factors
(such as SMAD3/4 and ETS-1) can induce activation of multiple HIF target genes under hypoxic

Regulation of gene expression under hypoxic conditions

K Nakayama, N Kataoka - International journal of molecular sciences, 2019 - mdpi.com
… Some transcription factors are activated under hypoxic … increases expression of anti-apoptotic
genes in hepatocytes, … co-activators and thereby induces expression of its target genes [75]…

[PDF][PDF] Hypoxia‐inducible factor‐2α reprograms liver macrophages to protect against acute liver injury through the production of interleukin‐6

RY Gao, M Wang, Q Liu, D Feng, Y Wen, Y Xia… - …, 2020 - Wiley Online Library
… and transcription factor 3 activation in hepatocytes, as well as … (18,19) HIF is a key transcription
factor that is activated in a … that hypoxia induced IL-6 production in WT hepatic MΦs but …

Hypoxia inducible factor‐1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway

J Han, Y He, H Zhao, X Xu - Journal of cellular biochemistry, 2019 - Wiley Online Library
… HIF-1α mRNA expression from the nuclear extract of isolated … As shown in Figure 4A, HTFD
induced NFkb activation in wild… NF-kb-p65 signaling was activated in the liver of high-fat-diet …

Liver zonation in health and disease: hypoxia and hypoxia-inducible transcription factors as concert masters

T Kietzmann - International journal of molecular sciences, 2019 - mdpi.com
Hypoxia exerts a feedback and activates expression of HIF … Hypoxia was able to induce
SHH, and PTCH1 expression as … However, both activation of the WNT pathway via R-spondin …

[HTML][HTML] Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway

J Chen, J Chen, H Fu, Y Li, L Wang… - American Journal of …, 2019 - journals.physiology.org
… The hypoxia-inducible factor (HIF) family activates the … PPARα activation. Thus we propose
that HIF-2α overexpression … induced by hypoxia exacerbates steatotic hepatocyte lipid …

Hypoxia and EGF stimulation regulate VEGF expression in human glioblastoma multiforme (GBM) cells by differential regulation of the PI3K/Rho-GTPase and MAPK …

S Nicolas, S Abdellatef, MA Haddad, I Fakhoury… - Cells, 2019 - mdpi.com
under normoxic conditions, EGF stimulates the activation of … HIF-1α triggers the expression
of a number of genes including … complete loss of hypoxia-induced VEGF expression (Figure 2…

Hypoxia-inducible factors and the regulation of lipid metabolism

I Mylonis, G Simos, E Paraskeva - Cells, 2019 - mdpi.com
… of which is a directly activated by HIF-1 [48]. Extracellular FA … under hypoxia is further favored
by the hypoxic induction of … under hypoxia by activation of the transcription factor PPARγ …

[HTML][HTML] YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

L Zhong, D Liao, M Zhang, C Zeng, X Li, R Zhang… - Cancer letters, 2019 - Elsevier
regulation of YTHDF2 was specifically induced by hypoxia in … cell proliferation, tumor growth
and activation of MEK and … resistance through gene regulation by hypoxia-inducible factor (…