[HTML][HTML] ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome …
Z Chen, C Wu, Y Liu, H Li, Y Zhu, C Huang, H Lin… - Cell Death & …, 2020 - nature.com
… inflammasome recruits these three components and cleaves pro-caspase-1 to an active form
(cleavage caspase-1) … NLRP3 inflammasome has been reported to play a fundamental role …
(cleavage caspase-1) … NLRP3 inflammasome has been reported to play a fundamental role …
Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension
… and others have shown that NLRP3 inflammasome activity is essential for the development
of … Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced …
of … Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced …
IL-18 (Interleukin-18) produced by renal tubular epithelial cells promotes renal inflammation and injury during deoxycorticosterone/salt-induced hypertension in mice
… treatment with the NLRP3 inflammasome inhibitor, MCC950… one-kidney/deoxycorticosterone
acetate/salt (1K/DOCA/salt)-… suggest that IL-18 is an important regulator of T cell function in …
acetate/salt (1K/DOCA/salt)-… suggest that IL-18 is an important regulator of T cell function in …
[HTML][HTML] Multifactorial functions of the inflammasome component NLRP3 in pathogenesis of chronic kidney diseases
SR Mulay - Kidney international, 2019 - Elsevier
… Although the NLRP3 inflammasome complex plays a critical … various inflammasome
components is regulated by signal 1 … of inflammasome-related genes are strongly induced by …
components is regulated by signal 1 … of inflammasome-related genes are strongly induced by …
[HTML][HTML] The role of inflammasome-dependent and inflammasome-independent NLRP3 in the kidney
YG Kim, SM Kim, KP Kim, SH Lee, JY Moon - Cells, 2019 - mdpi.com
… is essential for NLRP3 inflammasome activation in … induced activation of the NLRP3
inflammasome in the kidney [72]. We ascertained the possibility of upregulated autophagic activity …
inflammasome in the kidney [72]. We ascertained the possibility of upregulated autophagic activity …
[HTML][HTML] NLRP3 inflammasome in metabolic-associated kidney diseases: an update
W Xiong, XF Meng, C Zhang - Frontiers in immunology, 2021 - frontiersin.org
… in MS is a very important part of the prevention and treatment of CKD. This article summarizes
the important role of inflammasome in renal damage caused by different metabolic factors, …
the important role of inflammasome in renal damage caused by different metabolic factors, …
[HTML][HTML] NLRP3 inflammasome and mineralocorticoid receptors are associated with vascular dysfunction in type 2 diabetes mellitus
… an excess of aldosterone induces vascular dysfunction in … assembly of the NLRP3
inflammasome. Mesenteric resistance … the important role of NLRP3 inflammasome activation and …
inflammasome. Mesenteric resistance … the important role of NLRP3 inflammasome activation and …
[HTML][HTML] Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome
LA Ertuglu, AP Mutchler, J Yu, A Kirabo - Frontiers in Physiology, 2022 - frontiersin.org
… We further found that high salt-induced activation of NLRP3 inflammasome is ENaC- and …
Emerging evidence demonstrates that inflammasome activation and pyroptosis are important …
Emerging evidence demonstrates that inflammasome activation and pyroptosis are important …
[HTML][HTML] Involvement of inflammasome components in kidney disease
… Furthermore, patient comorbidities and treatments seem important drivers of inflammasome
… As a result, the inflammasome acts as a detector, and its induction is a frequent way for cells …
… As a result, the inflammasome acts as a detector, and its induction is a frequent way for cells …
[HTML][HTML] Emerging role of the inflammasome and pyroptosis in hypertension
… exaggerated renal NLRP3 inflammasome activation after an aldosterone-induced renal
damage … the NLRP3 inflammasome and the consequent pyroptosis as important mediators of …
damage … the NLRP3 inflammasome and the consequent pyroptosis as important mediators of …