… the clinical impact of delayed or inappropriate antimicrobial … defined as antimicrobial coverage
that provides adequate in … data to develop institution-specific guidelines for the treatment …

… Both aims are especially relevant in sepsis guidelines [9]. The importance of prompt … -based
empiric antibiotic policies and estimate the effects on treatment adequacy and antimicrobial …

… for observational studies and a checklist of proposed guidelines for the reporting of PSM [20]. …
The complexity of the confounders that influence the adequacy of empiric treatment are …

… the differential effect of antibiotic delays in sepsis versus septic … of adequate empiric antibiotic
therapy in sepsis as well as … modeling or institution-specific pharmacokinetic calculators [96]…

… the potential impact of an early sepsis treatment algorithm, … by local guidelines), or atypical
antimicrobial coverage was … can be powered by institution-specific predictive models that …

… discontinue empiric antimicrobial therapy when infection can … Therefore, we propose the
option of adequate high-dose … Clinical impact of gram-negative nonfermenters on adults …

… of institution-specific guidelines for empiric double coverage of gram-negative infections, based
on the adequacy of different empiric antibiotic … impact of inappropriate initial antimicrobial …

… evaluating PCT to effect changes on empiric antibiotic use or … programme: an institution-specific
educational programme by a … to maintain adequate (or to decrease) rates of antimicrobial …

… In a 2013 study on the positive impact of a sepsis protocol in a … Impact of adequate empirical
antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis…

… , institution-specific antibiograms and treatment guidelines, … likely to have the greatest impact
in the ICU setting. … Klebsiella infection in the ICU (p < 0.001), empiric antibiotic prescriptions …