… Hypotension produced reproducible increases in pial artery … Papaverine-induced (10 −8 ,
10 −6 M) pial artery dilation … via what we have historically termed the permissive effect of NO. In …

… vasodilator (IPVD) therapy either in the form of nitric oxide (… target PaO 2 8kPa with permissive
hypercapnia. Where this could … pulmonary vascular resistance, reduced pulmonary arterial …

… is a permissive post-translational modification, leading to an … dysfunction can be reversed
by improving BH 4 availability in … in lung vasculature and its activity is increased in pulmonary …

… Many authors have discouraged permissive hypercapnia in … This vasoconstriction may be
reversed using iNO (240). In contrast, … Nitric oxide deficiency and endothelial dysfunction in …

… effects of eNOS overexpression being reversed by the non-… , such as for the treatment of
pulmonary artery hypertension. … streptozotocin-induced diabetes, indicating that increased iNOS …

… CO2 modulates the pulmonary vascular tone via alteration in nitric oxide (NO) release…
Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive …

… while also minimizing hemorrhage from damaged vasculature. Free nitric oxide (NO) is a
potent … We propose to augment SNO-Hb levels via inhalation of the s-nitrosylating agent ethyl …

… degree of permissive hypercapnia and acidosis can affect the … Adjunctive respiratory therapies
such as inhaled nitric oxide … resulting in a rapid increase in PBF and reversal of the ductal …

… ventilation often lead to reversal of the pathophysiological … nitric oxide synthase (NOS)
from the terminal nitrogen of L-… , and a degree of permissive hypercapnia are recommended …

… Each attending physician could manage refractory hypoxemia and/or hypercapnia with
nitric oxide, prone positioning and/or ECMO, at their discretion. The ECCO 2 R treatment was …