Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis

D Lacedonia, G Scioscia, P Soccio, M Conese… - BMC pulmonary …, 2021 - Springer
… In particular, miR-26a function is to down-regulate the expression of … functions as a silencer
of let-7d. As a consequence, let-7d is prevented from its physiological action of inhibiting

MicroRNA Let-7d Mediated Mesenchymal Stem Cell Exosomes Against Idiopathic Pulmonary Fibrosis Through Epithelial-Mesenchymal Transition Progress

J Liu, X Han, M Gu, Q Zhao, Q Li, X Liu - 2024 - researchsquare.com
… in the si-Let-7d group compared to that in the inhibitor NC group. … miRNA Let-7d mimics or
miRNA Let-7d inhibitors in MSCs. … Inhibition and role of let-7d in idiopathic pulmonary brosis. …

ADAR1 Isoforms Regulate Let-7d Processing in Idiopathic Pulmonary Fibrosis

G Díaz-Piña, K Rubio, RM Ordoñez-Razo… - International Journal of …, 2022 - mdpi.com
Let-7d, we performed the experiment treating fibrotic fibroblasts with pentostatin, an inhibitor
… On the other hand, we did not explore the role of Let-7d in the conformation of the nucleolus …

MicroRNA let-7 downregulates ligand-independent estrogen receptor–mediated male-predominant pulmonary fibrosis

S Elliot, S Periera-Simon, X Xia, P Catanuto… - American journal of …, 2019 - atsjournals.org
… isolated from patients with idiopathic pulmonary fibrosis (IPF) … In contrast, 48 hours after
transfection with let-7d inhibitors and … We did not test for significance due to a small number of …

Role of MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal Transition

AR Cadena-Suárez… - International Journal of …, 2022 - mdpi.com
… On the other hand, in a pulmonary fibrosis rat model induced by intra-tracheal injection of
bleomycin, it was observed that prodigiosin attenuates pulmonary fibrosis by inhibiting miR-…

miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis

X Yu, R Zhai, B Hua, L Bao, D Wang, Y Li, W Yao… - RSC …, 2019 - pubs.rsc.org
… to explore the function and mechanism of miRNA let-7d in the … let-7d negatively regulated
silica-induced EMT and inhibited … has been found in human idiopathic pulmonary fibrosis (IPF) …

Low let7d exosomes from pulmonary vascular endothelial cells drive lung pericyte fibrosis through the TGFβRI/FoxM1/Smad/β‐catenin pathway

H Xie, YM Gao, YC Zhang, MW Jia… - Journal of Cellular …, 2020 - Wiley Online Library
… into the most common idiopathic pulmonary fibrosis (IPF) with … pericytes were transfected
with let-7d mimic, inhibitor or their … revealed that let-7d performed its roles of regulating fibrosis-…

Inhibition of miR-182-5p attenuates pulmonary fibrosis via TGF-β/Smad pathway

Y Chen, Q Zhang, Y Zhou, Z Yang… - Human & Experimental …, 2020 - journals.sagepub.com
function of miR-182-5p in pulmonary fibrosis, we established bleomycin (BLM)-induced
fibroticInhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med …

Current and prospective applications of exosomal microRNAs in pulmonary fibrosis

T Yang, J Wang, J Zhao, Y Liu - … Journal of Molecular …, 2022 - spandidos-publications.com
of lung injury and fibrosis and that miR-21 silencing inhibited … , miR-210 and let-7d were
downregulated in serum exosomes … cells alleviates idiopathic pulmonary fibrosis via interaction …

Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis

MS Njock, J Guiot, MA Henket, O Nivelles, M Thiry… - Thorax, 2019 - thorax.bmj.com
… in the sputum of patients with idiopathic pulmonary fibrosis (IPF). Characterisation of exosome-…
. Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med …