Epithelial‑derived exosomes promote M2 macrophage polarization via Notch2/SOCS1 during mechanical ventilation

Y Wang, W Xie, Y Feng, Z Xu, Y He… - International …, 2022 - spandidos-publications.com
… The inhibition of miR-221 has been found to ameliorate lipopolysaccharide (LPS)-induced …
The inhibition of miR-21a-5p (using miR-21a-5p antagomir) led to the inactivation of M2 …

MicroRNAs in diagnosis and therapeutics

C Atri, FZ Guerfali, D Laouini - AGO-driven Non-coding RNAs, 2019 - Elsevier
… -33 antagomir-treated mice showed reduction … murine breast cancer model [174]. On the
other hand, systemic delivery of miR-26a with AAVs in a mouse model of HCC led to inhibition

Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction: regulation of gene expression in the acute phase of ischemic stroke and …

M Daidone, M Cataldi, A Pinto… - Neural Regeneration …, 2021 - journals.lww.com
… These molecules are called antagomir, and their usage … in ischemic stroke patients or
animal models of ischemia using … reduced acute injury and ameliorated long-term neurological …

MicroRNA-30e-5p has an integrated role in the regulation of the innate immune response during virus infection and systemic lupus erythematosus

R Mishra, S Bhattacharya, BS Rawat, A Kumar… - Iscience, 2020 - cell.com
mouse model have shown higher expression of miR-30e. We also demonstrated an ex vivo
introduction of miR-30e antagomir … )-based inhibitor for miR-30e in SLE-induced mice that …

MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4

E Martino, N D'Onofrio, A Balestrieri, L Mele… - Cellular & Molecular …, 2023 - Springer
antagomiR denies the inflammatory pathway in both macrophages and septic mouse models
… i-PCSK9, able to ameliorate the endothelial inflammatory response during LPS treatment. …

Tuning into miRNAs: A comprehensive analysis of their impact on diagnosis, and progression in asthma

MA Elrebehy, AI Abulsoud, WA El-Dakroury… - … -Research and Practice, 2024 - Elsevier
… oligonucleotides or miRNA inhibitors can inhibit the activity of … This finding suggests that
miR-146a antagomir is a potential … interface cultures, in vivo animal models, and clinical samples …

Effects of Dendrimer-microRNA Nanoformulations against Glioblastoma Stem Cells

N Knauer, M Meschaninova, S Muhammad, D Hänggi… - Pharmaceutics, 2023 - mdpi.com
… Herein, we report a preclinical in vitro validation of antitumor activity of nanoformulations
containing antitumor microRNA miR-34a and microRNA-21 synthetic inhibitor and polycationic …

The impact of microRNAs during inflammatory bowel disease: effects on the mucus layer and intercellular junctions for gut permeability

S Stiegeler, K Mercurio, MA Iancu, SC Corr - Cells, 2021 - mdpi.com
… strategies that detect and ameliorate gut permeability. … mouse model and CD patient mucosal
biopsy samples [178]. Interestingly, the injection of a miR-7a-5p antagomir within mice that …

The therapeutic potential of microRNAs to ameliorate spinal cord injury by regulating oligodendrocyte progenitor cells and remyelination

S Qiu, H Dai, Y Wang, Y Lv, B Yu… - Frontiers in Cellular …, 2024 - frontiersin.org
… Overall, these studies indicated that miR-125a-3p synergistically inhibited OL differentiation
and … In a lidocaineinduced neurotoxicity model, the treatment of miR-199a-5p antagomiR

Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression

C Hu, Y Zhen, Z Ma, L Zhao, H Wu, C Shu, B Pang… - Molecular Therapy, 2023 - cell.com
… In humanized SLE model mice, MDSC depletion decreased the levels of Th17 cells,
accompanied by reduced expression of miR-542–5p and these polyamine synthetases. In addition, …