Two polyphenols with diverse mechanisms towards amyloidosis: differential modulation of the fibrillation pathway of human lysozyme by curcumin and EGCG
… as modulators of HuL amyloid aggregation and toxicity and unravelling their mechanism of
action. Curcumin exerts its inhibitory influence towards HuL fibrillation by interacting with the …
action. Curcumin exerts its inhibitory influence towards HuL fibrillation by interacting with the …
Elucidating the binding and inhibitory potential of p-coumaric acid against amyloid fibrillation and their cytotoxicity: Biophysical and docking analysis
MS Khan, MS Althobaiti, GS Almutairi, MS Alokail… - Biophysical …, 2022 - Elsevier
… Small molecules that inhibit protein aggregation and … used human lysozyme, a protein involved
in non-systemic amyloidosis, … Polyphenols has been reported earlier to block or attenuate …
in non-systemic amyloidosis, … Polyphenols has been reported earlier to block or attenuate …
Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin
K Siposova, T Kozar, V Huntosova, S Tomkova… - … et Biophysica Acta (BBA …, 2019 - Elsevier
… The cytotoxicity assay performed on the Neuro 2a … polyphenol, rottlerin, is capable to inhibit
amyloid fibril formation on each of the three tested amyloidogenic proteins, insulin, lysozyme, …
amyloid fibril formation on each of the three tested amyloidogenic proteins, insulin, lysozyme, …
Inhibition of amyloid fibrillation by small molecules and nanomaterials: strategic development of pharmaceuticals against amyloidosis
… is expected to be hindered as the phenolic rings interact with … can also inhibit fibrillation of
amylin and associated toxicity in … to inhibit and disintegrate the amyloid fibrils of lysozyme and …
amylin and associated toxicity in … to inhibit and disintegrate the amyloid fibrils of lysozyme and …
Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation
… aid the characterization of amyloid aggregates along with several models that might be
responsible for amyloid induced cytotoxicity to cells. Overview on the inhibition of amyloidosis by …
responsible for amyloid induced cytotoxicity to cells. Overview on the inhibition of amyloidosis by …
Effect of curcumin derivatives on hen egg white lysozyme amyloid fibrillation and their interaction study by spectroscopic methods
L Cui, S Wang, J Zhang, M Wang, Y Gao, L Bai… - … Acta Part A: Molecular …, 2019 - Elsevier
… Both of the two cucumin derivatives have displayed low cytotoxicity with HeLa cell. … phenolic
OH group and β-diketone moiety played important role in the inhibition of amyloid fibrillation. …
OH group and β-diketone moiety played important role in the inhibition of amyloid fibrillation. …
Lysozyme amyloid fibril: Regulation, application, hazard analysis, and future perspectives
Y Chen, Q Liu, F Yang, H Yu, Y Xie, W Yao - International Journal of …, 2022 - Elsevier
… Among them, NPs are mainly used as inhibitors as targeted … studied for polyphenols and
flavonoids natural products and … of lysozyme amyloid fibrils but the cytotoxicity of amyloids …
flavonoids natural products and … of lysozyme amyloid fibrils but the cytotoxicity of amyloids …
Attenuation of human lysozyme amyloid fibrillation by ACE inhibitor captopril: a combined spectroscopy, microscopy, cytotoxicity, and docking study
L Jin, C Liu, N Zhang, R Zhang, M Yan… - …, 2021 - ACS Publications
… polyphenols, which can significantly interfere with the formation of Aβ, α-synuclein (αS), and
lysozyme and insulin amyloid … known as inhibitors of amyloid fibrillation and can reduce the …
lysozyme and insulin amyloid … known as inhibitors of amyloid fibrillation and can reduce the …
Pomegranate seed polyphenol-based nanosheets as an efficient inhibitor of amyloid fibril assembly and cytotoxicity of HEWL
… -specific techniques to compare the efficacy of bulk and nano forms of PFPS in modulating
hen egg white lysozyme (HEWL) amyloid fibrillation process. HEWL is one of the most …
hen egg white lysozyme (HEWL) amyloid fibrillation process. HEWL is one of the most …
Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism
W Gao, L Jin, C Liu, N Zhang, R Zhang… - International Journal of …, 2021 - Elsevier
… could sharply reduce the amyloid fibrillation of HL. Additionally, … SA and SC can significantly
inhibit amyloid fibrillation of HL. … phenolic hydroxyl groups, as well as the hydrophobic cavity. …
inhibit amyloid fibrillation of HL. … phenolic hydroxyl groups, as well as the hydrophobic cavity. …