[HTML][HTML] The role of epoxyeicosatrienoic acids in cardiac remodeling
J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
… cardiac ATP-sensitive K + channels, enhanced L-type calcium currents, and improved cardiac
… Treatment with sEH inhibitor limited the cardiac fibrosis after MI, which is dependent on …
… Treatment with sEH inhibitor limited the cardiac fibrosis after MI, which is dependent on …
Omega‐3 polyunsaturated fatty acids and hypertension: a review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid
CI Bercea, GS Cottrell, F Tamagnini… - British Journal of …, 2021 - Wiley Online Library
… depolarisation increases calcium entry via L-type VGCC a … cell, EET, epoxyeicosatrienoic
acids. eNOS, endothelial nitric … combined inhibition of NOS and both SK Ca and IK Ca are …
acids. eNOS, endothelial nitric … combined inhibition of NOS and both SK Ca and IK Ca are …
Epoxyeicosatrienoic acid prevents maladaptive remodeling in pressure overload by targeting calcineurin/NFAT and Smad-7
X Li, G Chu, F Zhu, Z Zheng, X Wang, G Zhang… - Experimental Cell …, 2020 - Elsevier
… Multiple effects of EET on cardiac ion channels have been observed, … + channels and L-type
Ca 2+ channels in cardiomyocytes and inhibition of cardiac Na + channels and L-type Ca 2+ …
Ca 2+ channels in cardiomyocytes and inhibition of cardiac Na + channels and L-type Ca 2+ …
… of the mechanisms underlying the vascular relaxation mediated by n-3 PUFAs (fish oils), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in resistance …
R Limbu - 2019 - centaur.reading.ac.uk
… , mostly via the use of pharmacological inhibitors. Stable cells that allowed … Voltage-gated
calcium channels cGMP … AA can be converted into epoxyeicosatrienoic acids (EETs) and …
calcium channels cGMP … AA can be converted into epoxyeicosatrienoic acids (EETs) and …
Unraveling the role of 12-and 20-HETE in cardiac pathophysiology: G-protein–coupled receptors, pharmacological inhibitors, and transgenic approaches
JV Pascale, PA Lucchesi, V Garcia - Journal of cardiovascular …, 2021 - journals.lww.com
… epoxyeicosatrienoic acid (EET) and hydroxyeicosatetraenoic … [Ca 2+ ] through increased
Ca 2+ entry via the L-type Ca 2+ … phosphorylation of MaxiKβ (BK ca channel β subunit) that …
Ca 2+ entry via the L-type Ca 2+ … phosphorylation of MaxiKβ (BK ca channel β subunit) that …
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
JWH Leow, ECY Chan - Pharmacology & Therapeutics, 2024 - Elsevier
… acid, to regioisomeric bioactive epoxyeicosatrienoic acid (… effects including regulation of
cardiac electrophysiology. From … of cardiac electrophysiology due to the ion channel activities …
cardiac electrophysiology. From … of cardiac electrophysiology due to the ion channel activities …
CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes
EA Evangelista, T Aliwarga, N Sotoodehnia… - Scientific reports, 2020 - nature.com
… acid epoxide metabolites (epoxyeicosatrienoic acids, EETs) … that in the presence of a known
CYP2J2 inhibitor, danazol (DAN), … on ion channels, specifically L-type calcium channels and …
CYP2J2 inhibitor, danazol (DAN), … on ion channels, specifically L-type calcium channels and …
Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
J Atone, K Wagner, K Hashimoto… - Prostaglandins & Other …, 2020 - Elsevier
… epoxyeicosatrienoic acids (EETs) and the eicosapentaenoic … , and inhibition of these Ca
2+ currents by a Ca 2+ channel … block Ca V 1.3 l-type Ca 2+ channels in a porcine cardiac …
2+ currents by a Ca 2+ channel … block Ca V 1.3 l-type Ca 2+ channels in a porcine cardiac …
Bidirectional TRP/L Type Ca2+ Channel/RyR/BKCa Molecular and Functional Signaloplex in Vascular Smooth Muscles
… for the treatment of cardiovascular pathologies. Current … cerebral artery in response to
epoxyeicosatrienoic acids (EETs, … In this study, we demonstrate that the BK Ca channels inhibitor, …
epoxyeicosatrienoic acids (EETs, … In this study, we demonstrate that the BK Ca channels inhibitor, …
Recent advances in TRPV4 agonists and antagonists
BG Lawhorn, EJ Brnardic, DJ Behm - Bioorganic & Medicinal Chemistry …, 2020 - Elsevier
… of arachidonic acid including 5,6-epoxyeicosatrienoic acid (5,6-… blood pressure, heart rate
and cardiac output, which was … 9 showed attenuated l-type calcium channel inhibition (IC 50 …
and cardiac output, which was … 9 showed attenuated l-type calcium channel inhibition (IC 50 …