[HTML][HTML] The role of epoxyeicosatrienoic acids in cardiac remodeling

J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
cardiac ATP-sensitive K + channels, enhanced L-type calcium currents, and improved cardiac
… Treatment with sEH inhibitor limited the cardiac fibrosis after MI, which is dependent on …

Omega‐3 polyunsaturated fatty acids and hypertension: a review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid

CI Bercea, GS Cottrell, F Tamagnini… - British Journal of …, 2021 - Wiley Online Library
… depolarisation increases calcium entry via L-type VGCC a … cell, EET, epoxyeicosatrienoic
acids. eNOS, endothelial nitric … combined inhibition of NOS and both SK Ca and IK Ca are …

Epoxyeicosatrienoic acid prevents maladaptive remodeling in pressure overload by targeting calcineurin/NFAT and Smad-7

X Li, G Chu, F Zhu, Z Zheng, X Wang, G Zhang… - Experimental Cell …, 2020 - Elsevier
… Multiple effects of EET on cardiac ion channels have been observed, … + channels and L-type
Ca 2+ channels in cardiomyocytes and inhibition of cardiac Na + channels and L-type Ca 2+ …

… of the mechanisms underlying the vascular relaxation mediated by n-3 PUFAs (fish oils), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in resistance …

R Limbu - 2019 - centaur.reading.ac.uk
… , mostly via the use of pharmacological inhibitors. Stable cells that allowed … Voltage-gated
calcium channels cGMP … AA can be converted into epoxyeicosatrienoic acids (EETs) and …

Unraveling the role of 12-and 20-HETE in cardiac pathophysiology: G-protein–coupled receptors, pharmacological inhibitors, and transgenic approaches

JV Pascale, PA Lucchesi, V Garcia - Journal of cardiovascular …, 2021 - journals.lww.com
epoxyeicosatrienoic acid (EET) and hydroxyeicosatetraenoic … [Ca 2+ ] through increased
Ca 2+ entry via the L-type Ca 2+ … phosphorylation of MaxiKβ (BK ca channel β subunit) that …

CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control

JWH Leow, ECY Chan - Pharmacology & Therapeutics, 2024 - Elsevier
acid, to regioisomeric bioactive epoxyeicosatrienoic acid (… effects including regulation of
cardiac electrophysiology. From … of cardiac electrophysiology due to the ion channel activities …

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

EA Evangelista, T Aliwarga, N Sotoodehnia… - Scientific reports, 2020 - nature.com
acid epoxide metabolites (epoxyeicosatrienoic acids, EETs) … that in the presence of a known
CYP2J2 inhibitor, danazol (DAN), … on ion channels, specifically L-type calcium channels and …

Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases

J Atone, K Wagner, K Hashimoto… - Prostaglandins & Other …, 2020 - Elsevier
epoxyeicosatrienoic acids (EETs) and the eicosapentaenoic … , and inhibition of these Ca
2+ currents by a Ca 2+ channel … block Ca V 1.3 l-type Ca 2+ channels in a porcine cardiac

Bidirectional TRP/L Type Ca2+ Channel/RyR/BKCa Molecular and Functional Signaloplex in Vascular Smooth Muscles

DO Dryn, MI Melnyk, D Melanaphy, IV Kizub… - Biomolecules, 2023 - mdpi.com
… for the treatment of cardiovascular pathologies. Current … cerebral artery in response to
epoxyeicosatrienoic acids (EETs, … In this study, we demonstrate that the BK Ca channels inhibitor, …

Recent advances in TRPV4 agonists and antagonists

BG Lawhorn, EJ Brnardic, DJ Behm - Bioorganic & Medicinal Chemistry …, 2020 - Elsevier
… of arachidonic acid including 5,6-epoxyeicosatrienoic acid (5,6-… blood pressure, heart rate
and cardiac output, which was … 9 showed attenuated l-type calcium channel inhibition (IC 50 …