μ-Opioid receptors on distinct neuronal populations mediate different aspects of opioid reward-related behaviors

AL Severino, N Mittal, JK Hakimian, N Velarde… - eneuro, 2020 - eneuro.org
… cycle with ad libitum access to food and water, and experiments … MORs from D1
receptor-expressing neurons prevents opioid-… both A2a and μ opioid but not necessarily D2 …

Effect of selective lesions of nucleus accumbens µ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1 …

JM Bossert, CA Mejias-Aponte, T Saunders… - Journal of …, 2023 - Soc Neuroscience
… -Cre rats and had a stronger inhibitory effect on the effort to self… addictive effects of opioid
drugs. However, in rat models of … and third base pair of the stop codon located in Oprm1 exon 4. …

[HTML][HTML] Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement

F Chaudun, L Python, Y Liu, A Hiver, J Cand, BL Kieffer… - Nature, 2024 - nature.com
… Among the opioid receptors, µ-opioid receptors have a key … Here we injected mice with
fentanyl to acutely inhibit γ-… of the µ-opioid receptors (µORs) prevents the induction of …

Blocking μ-opioid receptors attenuates reinstatement of responding to an alcohol-predictive conditioned stimulus through actions in the ventral hippocampus

MR LeCocq, P Chander, N Chaudhri - Neuropsychopharmacology, 2023 - nature.com
… Importantly, we show that blocking MORs in the vHipp prevents … to δ-opioid receptors (DORs)
and κ-opioid receptors (KORs), … removing the inhibitory influence on GABA transmission. …

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition

Z Wang, C Jiang, H Yao, O Chen, S Rahman, Y Gu… - Brain, 2021 - academic.oup.com
… interaction between µ-opioid receptor isoform 1D (MOR1D) … s to prevent thermal injury.
Tail-flick latency was determined … that intrathecal opioid acts upon MORs on spinal inhibitory

Dopamine and opioids inhibit synaptic outputs of the main island of the intercalated neurons of the amygdala

GC Gregoriou, SA Kissiwaa, SD Patel… - European Journal of …, 2019 - Wiley Online Library
… of dopamine D1-receptor and μ-opioid receptor, release … required for synaptic experiments
prevents description of the … from these inputs both inhibits GABAergic transmission (red) …

Nalmefene attenuates reinstatement of methamphetamine-seeking behavior in rats through group II metabotropic glutamate receptors (mGluR2/3)

Y Nawata, R Ooishi, T Nishioku… - Behavioural Brain …, 2024 - Elsevier
… that both μ opioid receptors (MORs) and κ opioid receptors (… DA and Glu transmission in
the ventral tegmental area and its … prevents the inhibitory effects of N-acetylcysteine on drug-…

[HTML][HTML] Opioid-Induced Reductions in Amygdala Lateral Paracapsular GABA Neuron Circuit Activity

JW Ronström, NL Johnson, ST Jones… - International journal of …, 2023 - mdpi.com
… is regulated by two groups of inhibitory gamma aminobutyric … neurons highly express
inhibitory μ-opioid receptors (MORs) [16… The widefield epifluorescent and brightfield transmitted

Kappa opioid receptors drive a tonic aversive component of chronic pain

SS Liu, S Pickens, NE Burma… - Journal of …, 2019 - Soc Neuroscience
… effects in both male and female naive mice, but did not prevent … The rewarding effects of
intra-VTA injection of the μ-opioid … Because KOR inhibition by JDTic recovered morphine-evoked …

[HTML][HTML] Frequency of the dopamine receptor D3 (rs6280) vs. opioid receptor µ1 (rs1799971) polymorphic risk alleles in patients with opioid use disorder: a …

MC Gondré-Lewis, I Elman, T Alim, E Chapman… - Biomedicines, 2022 - mdpi.com
… had no effect in opioid-naive rats, such blockade prevented the … the µ opioid receptor, which
is a potent mediator of the opioids’ … via two distinct opioid receptors: (a) inhibition via µ opioid