Opioid Dependence, Tolerance, and Withdrawal
CJ Carranza-Aguilar, MT Rivera-García… - Opioids: Pharmacology …, 2022 - Springer
… The activation of these opioid receptors inhibits GABA release preventing … opioid receptor
agonist tramadol (μ-opioid receptor agonist and serotonin/norepinephrine transporter inhibitor) …
agonist tramadol (μ-opioid receptor agonist and serotonin/norepinephrine transporter inhibitor) …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is … for compulsive drug seeking
via negative reinforcement. … in dopamine, enkephalin/endorphin opioid peptide, and γ-…
via negative reinforcement. … in dopamine, enkephalin/endorphin opioid peptide, and γ-…
The transition to compulsion in addiction
… Opioids, by contrast, inhibit inhibitory interneurons that express the µ-opioid receptor and …
or degrading the contingency does not prevent food-seeking behaviour in some animals, …
or degrading the contingency does not prevent food-seeking behaviour in some animals, …
Ghrelin and food reward
… vagus nerve terminals and transmission of information to the … Both ghrelin and opioids act
in the same areas, including the … effects of opiates since pharmacological inhibition of ghrelin …
in the same areas, including the … effects of opiates since pharmacological inhibition of ghrelin …
Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect
… -coupled receptors, namely, the μ-opioid peptide receptor (MOP… However, both opioid agonists
inhibited NSPC-derived … researchers to prevent relapse in patients recovering from opioid …
inhibited NSPC-derived … researchers to prevent relapse in patients recovering from opioid …
Potential therapeutic targets for the treatment of opioid abuse and pain
… Although μ-opioid peptide (MOP) receptor agonists are … growth factor inhibitors, voltage-gated
sodium channel inhibitors, and … Nonetheless, pretreatment with tabernanthalog prevented …
sodium channel inhibitors, and … Nonetheless, pretreatment with tabernanthalog prevented …
[HTML][HTML] Aberrant feeding and growth in neonates with prenatal opioid exposure: evidence of neuromodulation and behavioral changes
E Yen, JL Maron - Frontiers in Pediatrics, 2022 - frontiersin.org
… be explained by the role of μ-opioid receptor (MOR) in the … reduced food seeking after
ingestion of palatable food, … and prevent the development of metabolic syndrome in opioid-…
ingestion of palatable food, … and prevent the development of metabolic syndrome in opioid-…
Accumbal μ-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics
AR Bischoff, R Dalle Molle, AB Mucellini, I Pokhvisneva… - Stress, 2024 - Taylor & Francis
… NaCl)) as part of the spectrum of palatable foods and sought to 1) model the effect of fetal
growth … The dopaminergic mesocorticolimbic pathway and the accumbal opioid system are two …
growth … The dopaminergic mesocorticolimbic pathway and the accumbal opioid system are two …
Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats
… Glutamatergic transmission is specifically implicated in forming associative memories,
during both the opioid experience and opioid withdrawal. NMDARs and μ-opioid receptors (MORs…
during both the opioid experience and opioid withdrawal. NMDARs and μ-opioid receptors (MORs…
Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction
CB Pantazis, LA Gonzalez, BJ Tunstall… - Science …, 2021 - science.org
… to pain-induced decreased μ-opioid receptor activation of the … of opioids, including the
μ-opioid and cannabinoid receptor … the PAG, and the inhibition of these factors reduced somatic …
μ-opioid and cannabinoid receptor … the PAG, and the inhibition of these factors reduced somatic …