Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

T Liu, S Luo, P Libby, GP Shi - Pharmacology & therapeutics, 2020 - Elsevier
inhibitors that block coronavirus entry into cultured host cells and provide a mechanism to
block … The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) crystal structure …

[HTML][HTML] Simultaneous treatment of COVID-19 with serine protease inhibitor camostat and/or cathepsin l inhibitor?

S Bittmann, A Weissenstein, G Villalon… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … serine protease 2 (TMPRSS2),
for cell entry [2]. … Camostat has the potential to block the entry of the virus into the lung …

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

A Pišlar, A Mitrović, J Sabotič, U Pečar Fonović… - PLoS …, 2020 - journals.plos.org
… later became known as Severe Acute Respiratory Syndrome (SARS) [… Cathepsin L is shown
in blue, cathepsin L III inhibitor is … Teicoplanin was recently shown to prevent the entrance of …

Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection

P Mitra - American Journal of Physiology-Cell Physiology, 2020 - journals.physiology.org
… like cathepsin L to mediate entry following fusion at the endosomal membrane through
the late pathway (53). Type II transmembrane serine proteases (TTSPs), play a critical role in …

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

MM Zhao, WL Yang, FY Yang, L Zhang… - Signal transduction and …, 2021 - nature.com
… -1 S protein, which is necessary for entry of coronavirus into host cells. Therefore, plasma
levels … target for inhibitors that could not only inhibit entry of the virus but also block the vicious …

Cathepsin L in COVID-19: from pharmacological evidences to genetics

CP Gomes, DE Fernandes, F Casimiro… - Frontiers in cellular …, 2020 - frontiersin.org
… the involvement of Cathepsin L (CatL) in severe acute respiratory syndrome coronavirus 2 (…
infection, its inhibition could be an alternative pathway to block its entry and release from host …

Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2

S Mondal, Y Chen, GJ Lockbaum, S Sen… - Journal of the …, 2022 - ACS Publications
… against severe acute respiratory syndrome coronavirus 2 (… inhibit Cathepsin L (CatL) which
is associated with viral entry … simultaneously block viral replication as well as further entry

[HTML][HTML] Food proteins are a potential resource for mining cathepsin L inhibitory drugs to combat SARS-CoV-2

A Madadlou - European Journal of Pharmacology, 2020 - Elsevier
… The entry of SARS-CoV-2 into host cells proceeds by a … inhibition might be useful in fine
targeting of cathepsin L. … able to inhibit cathepsin L and hence assist COVID-19 prevention. Food …

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro

B Mao, VTK Le-Trilling, K Wang… - Emerging Microbes & …, 2022 - Taylor & Francis
… the emerging severe acute respiratory syndrome coronavirus 2 (… of the endosomal cysteine
protease cathepsin L. Additionally, … inhibitors prevents severe acute respiratory syndrome

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

…, A Liang, F Zou, B Liu, F Hu, X Tang, L Li… - Frontiers in …, 2022 - frontiersin.org
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), … can cause severe respiratory
diseases, such as severe acute … might also be able to block the entry of SARS-CoV-2. Thus, …