Peptide-based inhibitors of fimbrial biogenesis in Porphyromonas gingivalis

SR Alaei, JH Park, SG Walker… - Infection and …, 2019 - Am Soc Microbiol
… inhibits extracellular polymerization of the Fim fimbriae, … FimA subunit inhibited polymerization
of the Fim fimbriae on the … subunit-subunit interactions and fimbrial polymerization, which …

Adhesion and invasion of gingival epithelial cells by Porphyromonas gulae

H Inaba, R Nomura, Y Kato, H Takeuchi, A Amano… - PloS one, 2019 - journals.plos.org
… significantly inhibited adhesion and invasion by P. gulae. … The numbers of adherent and/or
intracellular bacteria were … gingivalis fimbriae mediate bacterial interactions for host tissue …

Local and Systemic Effects of Porphyromonas gingivalis Infection

WA Chen, Y Dou, HM Fletcher, DS Boskovic - Microorganisms, 2023 - mdpi.com
gingivalis mutants to extracellular matrix (ECM) protein … gingivalis fimbriae serve dual functions
during the pathogenesis … human gingival epithelial cells is inhibited in a double knockout …

Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
… , fimbriae, and some other virulence factors are among the … enhancement of direct interaction
among the oral pathogens. … inflammasome, which enhanced the intracellular survival of P. …

[HTML][HTML] TLR2 activation by porphyromonas gingivalis requires both PPAD activity and fimbriae

A Wielento, GP Bereta, KB Łagosz-Ćwik… - Frontiers in …, 2022 - frontiersin.org
fimbriae purified from WT-ATCC 33277 and the delPPAD mutant strain, and then measured
the activation status of intracellular … the role of the interaction between these two factors is …

Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis

Z He, W Jiang, Y Jiang, J Dong, Z Song… - Journal of oral …, 2022 - Taylor & Francis
… of extracellular polysaccharides (EPS), proteins, lipids, and … coumarin exhibited a potent
inhibitory effect against QS systems, … gingivalis possesses two distinct types of fimbria, which are …

Molecular strategies underlying Porphyromonas gingivalis virulence

IL Silva, E Cascales - Journal of Molecular Biology, 2021 - Elsevier
… without inhibiting the overall inflammatory response.2, 3 P. … gingivalis fimbrial adhesins and
promotes its survival in … are either released into the extracellular medium or anchored to the …

Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications

H Mulhall, O Huck, S Amar - Microorganisms, 2020 - mdpi.com
… as lipopolysaccharide, proteases, fimbriae and a CRISPR-Cas … The amount of data illustrating
a relationship between … has demonstrated an inhibitory effect towards bacteria present …

Citrullination mediated by PPAD constrains biofilm formation in P. gingivalis strain 381

DM Vermilyea, GK Ottenberg, ME Davey - npj Biofilms and Microbiomes, 2019 - nature.com
gingivalis on protein substrates is inhibited at low pH and … We hypothesized that the
extracellular substance was a … for a greater number of interactions with fimbriae that may in …

Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis

G Hajishengallis, PI Diaz - Current oral health reports, 2020 - Springer
gingivalis fimbriae with TLR2 is promoted by an initial … The inhibitory effect on the production
of nitric oxide, a potent … complex and elevates intracellular cAMP levels for inhibiting cellular …