… Given the rapidly expanding knowledge of IGFBP actions … ambient IGFs in the cell culture
medium, might cause IGF1R … intracellular pathways distinct from IGF1R signal transduction, …

… belonging to the insulin and insulin-like growth factor-I (IGF-I) … in cultured thyroid epithelial
cells has been shown to activate … of the multiple downstream signal transduction pathways …

… action of signal transducer and activator of transcription 5b (… intact IGFBP-3 almost entirely
due to a faster off rate [102]. This … of the ECM in fibroblast cultures, which reduces its affinity for …

… The heart undergoes rapid growth in order to meet the … is a highly conserved system
regulating multiple cellular … with HASF inhibits apoptosis in culture and direct injection of HASF …

… IGF-I levels in the culture medium increased rapidly versus … The relationship between these
two signaling pathways is not … mediated intracellular signal transduction pathways that play …

… where there is rapid cell growth and proliferation resulting in … (PI3K) pathways which are
the two major pro-survival and pro-… The cells were cultured under normal non-stressed culture …

… After 15 min stimulation, mice were euthanised and the aorta rapidly … We did not observe
any discernible difference in the two … We cultured HUVECs in conditions aiming to recapitulate …

… and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling pathways
… Intracellular signal transduction by membrane receptors such as IR and IGF1R is primarily …

… Insulin-like growth factor I signalling pathways interact with … IGF-I at a time of rapid brain
growth and development is likely to be … In a co-culture system, impaired IGF-I signalling in human …

… and rapid … insulin-like growth factor I receptor (IGF-IR) as a potential therapeutic target for
TAO is now invigorating inquiry into potentially intersecting components of the IGF-I pathway …