… and to pinpoint the genes involved. The combination of MPseq … not incorporate comprehensive
proteomics, epigenomics, and … biallelic inactivation of numerous tumor suppressor genes …

… should follow a more coherent plan to pinpoint common vulnerabilities among these tumors.
… /SNF complexes to cancer arose from studies identifying biallelic inactivation of SMARCB1 …

… possibility of epigenetic dysregulations driving these tumors. … to pinpoint specific gene(s)
that are likely targeted from these … ratio in tumor between [0.2, 0.8]; Thirdly, only biallelic sites …

… given its role as an epigenetic regulator and a histone methylation … argue against a biallelic
type of mutational inactivation, which … As our WGS analysis did pinpoint important therapeutic …

… For example, mutated epigenetic regulators, transcription factors … data can pinpoint relevant
genes in such genomic regions, … of complexity, as biallelic gene inactivation is required. This …

… and within various tumors. Here… epigenomic landscape in cancer. We will focus mainly on
DNA methylation and post-translational histone modifications as the key regulatory epigenetic …

… genomic, proteomic, and epigenetic landscape, and discuss translational efforts to identify
patients at high risk of recurrence and tumors … in respective tumors while identical biallelic NF2 …

… -based therapeutics for these cancers. Prospective comprehensive genomic profiling could
… many sarcomas lack any specific gene signatures that can help pinpoint a specific subtype. …

… with 11q deletions, and biallelic ATM disruption led to … (NF-κB) signaling, and inactivation
or deletion of BIRC3 in CLL … CLL8 cohort allowed researchers to pinpoint patients with IGHV-…

… Genomic imprinting is an epigenetic process that causes … genetic complexity, Knudson’s
two-hit model of inactivation of a … genomic sequences were used to pinpoint candidate genes. A …