Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast …

JA Ankney, L Xie, JA Wrobel, L Wang, X Chen - BMC Medical Genomics, 2019 - Springer
… , our secreto-transcriptomic approach bypasses both the … to fully identify patient-specific
proteomic alterations, integrating … of multi-gene or multi-protein panels as systems signatures can …

Locally advanced rectal cancer transcriptomic-based secretome analysis reveals novel biomarkers useful to identify patients according to neoadjuvant …

LM Canto, SS Cury, MC Barros-Filho, BEC Kupper… - Scientific reports, 2019 - nature.com
… Plasma Proteome database confirmed the presence of the candidates in the blood … Our
main aim was to identify a molecular signature able to differentiate these patients. However, and …

Clinical value of multiomics-based biomarker signatures in inflammatory bowel diseases: challenges and opportunities

AR Bourgonje, H van Goor, KN Faber… - Clinical and …, 2023 - journals.lww.com
… disease classification, to identify disease biomarkers, and to … dynamic biomarkers (eg,
proteomic- or transcriptomic-based … use of integrative multiomics-based biomarker signatures to …

Increased DSG2 plasmatic levels identified by transcriptomic-based secretome analysis is a potential prognostic biomarker in laryngeal carcinoma

SS Cury, RML Lapa, JBH de Mello, FA Marchi… - Oral Oncology, 2020 - Elsevier
… between the over-expressed genes and the secretome-related databases (HPA: secretome
and plasma proteome and HCSD: HNSC secretome), we identified 31 potential LSCC …

Multi-omic approaches to breast cancer metabolic phenotyping: Applications in diagnosis, prognosis, and the development of novel treatments

N Gómez-Cebrián, I Domingo-Ortí, JL Poveda… - Cancers, 2021 - mdpi.com
… discovering novel biomarkers and identifying new therapeutic … Transcriptomic-based
approaches have characterized specific … employed integrated approaches to metabolically identify

The proteomic landscape of pancreatic ductal adenocarcinoma liver metastases identifies molecular subtypes and associations with clinical response

HCH Law, D Lagundžin, EJ Clement, F Qiao… - Clinical Cancer …, 2020 - AACR
… The consistencies between our proteomics-based and the transcriptomic-based classification
systems suggest that many of the same transcriptional signatures found in primary tumors …

Proteomic approaches for characterizing renal cell carcinoma

DJ Clark, H Zhang - Clinical Proteomics, 2020 - Springer
… , proteomic technologies offer a comprehensive methodology … compositions and proteomic
signatures. These four subtypes… identification of potential candidate protein biomarkers. This …

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

SV Lindskrog, F Prip, P Lamy, A Taber… - Nature …, 2021 - nature.com
… The classifier provides a framework for biomarker discovery … , we suggest the use of a
transcriptomic-based classifier, as the … We calculated a progression signature score for all 535 …

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

M Rydenfelt, M Wongchenko, B Klinger… - Life Science …, 2019 - life-science-alliance.org
… /proteomic signals may be alternative biomarker candidates … transcriptomic, proteomic, or
combined (late integration) data … A main challenge of identifying potential biomarkers from cell …

The proteomic landscape of soft tissue sarcomas

J Burns, CP Wilding, L Krasny, X Zhu… - Nature …, 2023 - nature.com
… functional signatures termed Sarcoma Proteomic Modules … We sought to establish if
biomarker(s) identified within each of … have reported transcriptomic-based molecular subgroups …