[HTML][HTML] … physiologically-based biopharmaceutics modeling (PBBM) approach to assess the in vivo performance of an orally administered drug product: from IVIVC to …
M Bermejo, B Hens, J Dickens, D Mudie, P Paixão… - Pharmaceutics, 2020 - mdpi.com
… should be integrated into biopredictive dissolution testing (low … poor aqueous solubility
and high permeability, these dynamic … The obtained underlying cumulative dissolution profile …
and high permeability, these dynamic … The obtained underlying cumulative dissolution profile …
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
T Heimbach, S Suarez-Sharp, M Kakhi, N Holmstock… - 2019 - Springer
… planning of incorporating IVIVCs in the drug development. … While the IVIVC development
strategy employed in this study … and highly permeable drug in the upper part of the intestine (…
strategy employed in this study … and highly permeable drug in the upper part of the intestine (…
Simultaneous Evaluation of Dissolution and Permeation of Oral Drug Solid Formulations for Predicting Absorption Rate–Limiting Factors and In Vitro–In Vivo …
Z Li, X He, S Tian, G Feng, C Huang, M Xun, Z Wu… - AAPS …, 2019 - Springer
… pH modifiers were integrated into the drug dissolution/absorption … and IVIVCs were predicted
from the dissolution–permeation–… on the dissolution profiles and the permeation dynamics …
from the dissolution–permeation–… on the dissolution profiles and the permeation dynamics …
Advances in in vivo predictive dissolution testing of solid oral formulations: how closer to in vivo performance?
M Shrivas, D Khunt, M Shrivas, M Choudhari… - … of Pharmaceutical …, 2020 - Springer
… integrated dissolution–absorption models, the dissolution/… dissolved drugs and cause less
disturbance in drug permeation. … very difficult to establish IVIVC for drugs especially exhibiting …
disturbance in drug permeation. … very difficult to establish IVIVC for drugs especially exhibiting …
Novel extended IVIVC combined with DoE to predict pharmacokinetics from formulation compositions
… with design of experiment (DoE) that integrates the DoE into … vitro dissolution and in vivo
drug concentrations, IVIVC allows … IVIVC methods has been limited to highly permeable drugs, …
drug concentrations, IVIVC allows … IVIVC methods has been limited to highly permeable drugs, …
Conventional vs Mechanistic IVIVC: A Comparative Study in Establishing Dissolution Safe Space for Extended Release Formulations
S Kollipara, T Ahmed, M Chougule, C Guntupalli… - AAPS …, 2024 - Springer
… validation, the virtual dissolution profiles were integrated into … and pharmaceutical scientists
to use mechanistic IVIVC’s for … systems such as dissolution/permeation (eg PermeaLoop™), …
to use mechanistic IVIVC’s for … systems such as dissolution/permeation (eg PermeaLoop™), …
Simultaneous analysis of dissolution and permeation profiles of nanosized and microsized formulations of indomethacin using the in vitro dissolution absorption …
J Li, LB Li, N Nessah, Y Huang, C Hidalgo… - … of Pharmaceutical …, 2019 - Elsevier
… developed an integrated in vitro dissolution-permeation system which consisted of the apical
dissolution and the basal permeation … The dissolution profiles of microsized and nanosized …
dissolution and the basal permeation … The dissolution profiles of microsized and nanosized …
[HTML][HTML] In vitro–In vivo correlation in the development of oral drug formulation: A screenshot of the last two decades
MG Davanco, DR Campos… - International Journal of …, 2020 - Elsevier
… of product development, it is necessary an integrated work of … on different drugs regarding
the application of IVIVC, and it … condition for dissolution and, consequently, permeability. Sub-…
the application of IVIVC, and it … condition for dissolution and, consequently, permeability. Sub-…
A Perspective on Model-Informed IVIVC for Development of Subcutaneous Injectables
CD Corpstein, T Li - Pharmaceutical Research, 2023 - Springer
… , integration of modeling and simulation with current IVIVC … III drugs may be eligible with an
IVIVC and high dissolution rates, … unpredictability of both low solubility and permeability [12]. …
IVIVC and high dissolution rates, … unpredictability of both low solubility and permeability [12]. …
Best practices for integration of dissolution data into physiologically based biopharmaceutics models (PBBM): a biopharmaceutics modeling scientist perspective
… (IVIVC) and clinically relevant dissolution specifications (CRDS) … to integrate dissolution data
(ie, virtual dissolution profiles … a BCS III molecule with permeability controlled absorption [27…
(ie, virtual dissolution profiles … a BCS III molecule with permeability controlled absorption [27…