… We established a comprehensive clinical genomics program for this patient group. The rate
of clinically relevant alterations across 515 patients with advanced solid tumors was 39% by …

… using both functional genomics and clinical genomics strategies to identify … cancer, we
applied a clinical genomics filter designed to prioritize CRISPRi hits with evidence of genomic …

… (ClinVar and the Human Genome Mutation Database), with pathogenicity determined as
per American College of Medical Genetics and Genomics guidelines. Only variants previously …

… In the era of precision oncology, few large-scale genomic studies have focused on metastatic
breast cancer, and hence, our understanding of the breast cancer genome has relied on …

… We review and synthesize recent major genomic studies of GCPM into 11 biologic hallmarks
across four categories, including tumor-related factors, the peritoneal microenvironment, …

… all cancer subtypes, tumour molecular profiling is now viewed by most oncologists as a
clinical necessity in all patients with metastatic cancer who require systemic therapy 6,84 . …

… clinical, molecular and host factors can influence the staging and treatment of patients with
metastatic cancer… with the goal of curing larger numbers of patients with metastatic cancers. …

… biomarker–linked targeted therapies where genomic testing would be … of metastatic cancer,
as well as in diseases without approved genomic biomarker–linked therapies, when genomic …

… Here, focusing on these data-rich cell types, we developed an integrative and network-associated
annotation, which may serve as a valuable resource for cancer genomics. …

… of the three cancer subtype classification … of integrative clinical, genomics, and
histopathological images data relied on extraction and fusion of the best features from the genomics …