[HTML][HTML] Adjuvant chemotherapy in elderly colorectal cancer patients

B Glimelius, E Osterman - Cancers, 2020 - mdpi.com
… in elderly patients to motivate the increased risks of toxicity … with adjuvant therapy, who
make up the majority of stage IIregimens becoming the reference treatment in colon cancer …

Relative Dose Intensity of Chemotherapy and Survival in Patients with Advanced Stage Solid Tumor Cancer: A Systematic Review and Meta-Analysis

CM Nielson, LC Bylsma, JP Fryzek, HA Saad… - The …, 2021 - academic.oup.com
… -, or FOLFIRINOX-based chemotherapy regimens, suggesting a … Although grade 3 or
higher hematologic toxicities occurred … , elderly patients are at increased risk of chemotherapy-…

[HTML][HTML] Impact of age on the use of adjuvant treatments in patients undergoing surgery for colorectal cancer: patients with stage III colon or stage II/III rectal cancer

C Sarasqueta, A Perales, A Escobar, M Baré… - BMC cancer, 2019 - Springer
… the use of adjuvant chemotherapy for stage III colon cancer … A greater toxicity of chemotherapy
and radiotherapy in older … frequency and severity of comorbidity among older patients. …

[HTML][HTML] Impact of relative dose intensity of oxaliplatin in adjuvant therapy among stage III colon cancer patients on early recurrence: a retrospective cohort study

J Żok, M Bieńkowski, B Radecka, J Korniluk… - BMC cancer, 2021 - Springer
… termination of chemotherapy due to oxaliplatin toxicity, which … colon cancer patients of
Caucasian race, age 18 or older, … The adjuvant chemotherapy included regimens with oxaliplatin …

Oxaliplatin-Based Adjuvant Chemotherapy in Older Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 12 Trials

C Gallois, Q Shi, LD Pederson, T André… - Journal of Clinical …, 2024 - ascopubs.org
… dose intensity was somewhat inferior in the older age group … FOLFOX regimens with more
grade3 hematological toxicity (… chemotherapy appears to be safe with manageable toxicities

[HTML][HTML] Development and validation of a risk tool for predicting severe toxicity in older adults receiving chemotherapy for early-stage breast cancer

A Magnuson, MS Sedrak, CP Gross… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
… with neoadjuvant or adjuvant chemotherapy were prospectively … , and chemotherapy regimens.
A tool that accounts for … , dose delays, reduced dose intensity, and hospitalizations. These …

Undertreatment and overtreatment in older patients treated with chemotherapy

J Feliu, E Espinosa, L Basterretxea, I Paredero… - Journal of geriatric …, 2021 - Elsevier
… in any stage; initiation of a new chemotherapy regimen (with/without … Chemotherapy intensity
for the first cycle of treatment was … to toxicity differences among chemotherapy regimens. …

[HTML][HTML] Patient-and tumor-related predictors of chemotherapy intolerance in older patients with cancer: a systematic review

DL van Abbema, M van den Akker… - Journal of geriatric …, 2019 - Elsevier
… as the occurrence of chemotherapy toxicity grade 3 to 5, … tumor type and chemotherapy
regimen. Studies which included … an association between comorbidity and chemotherapy toxicity. …

Management of the toxicity of chemotherapy and targeted therapies in elderly cancer patients

J Feliu, V Heredia-Soto, R Gironés… - Clinical and …, 2020 - Springer
… to chemotherapy, and depending on the degree of severity and clinical … In the elderly, the
effect of age on the toxicity of these drugs … In a phase III trial, it was reported that after 8 weeks of …

The use of chemotherapy in older patients with stage II and III colon cancer: variation by age and era of diagnosis

SL Green, DE Dawe, Z Nugent, WY Cheung… - Journal of geriatric …, 2019 - Elsevier
… of adjuvant chemotherapy in older patients with stage II or III … to severity of illness, social
supports, and environment [23]. … dataset to identify specific drugs. Furthermore, oxaliplatin only …