Assessing and modelling of post-traumatic stress disorder using molecular and functional biomarkers

K Skolariki, AG Vrahatis, MG Krokidis, TP Exarchos… - Biology, 2023 - mdpi.com
… Variants of FKBP5 have been found to significantly moderate … had significant interactions
with childhood trauma in … associated with relative resilience to childhood adversity [53]. Further …

FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents

JS Womersley, S Roeh, L Martin… - Brain Structure and …, 2022 - Springer
… We further investigated whether the interaction of CT and rs1360780 genotype influences …
whether the interaction of CT and AP scores was associated with FKBP5 methylation in order …

Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder

PC Chou, YC Huang, S Yu - Life, 2024 - mdpi.com
disorders can impair the interaction between the patient and their offspring, acting as a form
of childhood adversity [… found between F0 stress and lower FKBP5 methylation in offspring. …

Physiological genomics plays a crucial role in response to stressful life events, the development of aggressive behaviours, and post-traumatic stress disorder (PTSD)

T Magwai, KR Xulu - Genes, 2022 - mdpi.com
… behaviours and their interaction with anxiety disorders. This review … of childhood adversity;
however, only the rs9470080 SNP of … of the FKBP5 gene has been reported to affect the risk of …

The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach

AH Wani, AE Aiello, GS Kim, F Xue, CL Martin… - … of affective disorders, 2021 - Elsevier
… , severity, and prolonged course of post-traumatic stress disorder (PTSD), including:
comorbid and/or prior psychopathology; social adversity such as low socioeconomic position, …

FKBP51 in a dynamic environment

L van Doeselaar - 2023 - pure.mpg.de
… , anxiety disorders and posttraumatic stress disorders, … Exposure to early life adversity
has often been associated with … FKBP5 gene were found to interact with traumatic early life

The influences of genes and early life stress on the HPA axis regulation

D Wuergezhen - 2019 - fse.studenttheses.ub.rug.nl
… axis is posttraumatic stress disorder (PTSD… FKBP5 polymorphism effect: the interaction of
FKBP5 polymorphism (rs1360780 genotype) and childhood adversity is related to a higher risk

A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment

L Cao-Lei, D Saumier, J Fortin, A Brunet - Frontiers in psychiatry, 2022 - frontiersin.org
… As shown in a recent review (47) a growing body of studies on early life adversity in both …
group interaction in which responders exhibited an increase in FKBP5 methylation following …

FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder

B Cruz, V Vozella, BA Carper, JC Xu, D Kirson… - …, 2023 - nature.com
… of stress and alcohol history on the sensitivity to FKBP5 inhibitors, in two separate studies,
we administered two FKBP5 … may contribute to observed effects, including interactions with …

Interaction of FKBP5 variant rs3800373 and city living alters the neural stress response in the anterior cingulate cortex

A Richter, M Al-Bayati, F Paraskevopoulou, B Krämer… - Stress, 2021 - Taylor & Francis
… of stress-related disorders. Here we investigated the interaction of city living and genetic
variation in FKBP5 (rs3800373) on neural activity in stress-sensitive brain systems. Functional …