… beta-2-microglobulin and this interaction is essential … HFE hemochromatosis. Pathogenic
variants of TFR2 gene, which encodes the transferrin receptor 2, cause this type of hereditary …

… TfR2 forms a complex with hemochromatosis protein, HFE, and … systemic iron overload,
hemochromatosis, through down-… Thus, TfR1 can interact with two iron-carrier proteins with …

… that gene expression of HFE, transferrin receptor 1 (TfRC) and transferrin receptor 2 (TfR2)
on … loaded transferrin for the binding to the transferrin receptor, but it does not just interact with …

… HFE. Studies directed instead to examining the functional consequences of this interaction
on HFE … by which the interaction of HFE with TFR1 prevents HFE from otherwise exerting an …

… binding of the transferrin protein (TF) with the Transferrin Receptor 1 (TFR1) protein (responsible …
The TF-TFR1 binding displaces the HFE protein that then is free to interact with TFR2 to …

… HFE binds the extracellular domain of Transferrin Receptor 1 (TfR1), reducing the affinity of
TfR1 for transferrin… that HFE E168 was at the interface of the HFE-TfR1 interaction and made …

… that the hemochromatosis proteins [HFE, transferrin receptor 2 (TFR2) … Patients affected by
hemochromatosis type-1, -2, -3 have a … interactions with diferric transferrin (Tf-Fe2), transferrin …

… The hepatocytes also express transferrin receptor 2 (TFR2); however, its affinity for … highly
saturated transferrin stabilizes TfR2, disrupting the interaction between the HFE protein and …

… HFE interacts with transferrin receptor 2 (TFR2), leading to increased stabilization and activation
of bone morphogenic protein … interaction of the iron-transferrin complex with its receptor, …

… affinity when compared to the HFE-TfR1 interaction 20 20 Delima RD, Chua ACG, Tirnitz-Parker
JEE, et al. Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-…