Antioxidant genes and susceptibility to air pollution for respiratory and cardiovascular health

E Fuertes, DA van der Plaat, C Minelli - Free Radical Biology and Medicine, 2020 - Elsevier
… in the lower respiratory tract [23] and translocate into the circulation to cause cardiovascular
… GxE interaction effects between PM 2.5 and antioxidant genes for HRV were assessed in …

[HTML][HTML] Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals

CA Melbourne, AM Erzurumluoglu, N Shrine… - Environment …, 2022 - Elsevier
interaction effect for any statistically significant signal, we present the association between
lung function trait and air pollution … the most commonly evaluated antioxidant genes (for which …

Oxidative stress and air pollution: its impact on chronic respiratory diseases

MP Sierra-Vargas, JM Montero-Vargas… - International Journal of …, 2023 - mdpi.com
… in the pathophysiology of respiratory tract diseases (Figure 1). … the primary antioxidant
defenses of the respiratory system, and … factors, such as genetics and environmental exposures to …

An update on immunologic mechanisms in the respiratory mucosa in response to air pollutants

RD Huff, C Carlsten, JA Hirota - Journal of allergy and clinical immunology, 2019 - Elsevier
… a role for antioxidants in normalizing these negative effects. Genetic variants in genes important
in epithelial cell function … for air pollution in the respiratory mucosa are the airway surface …

[HTML][HTML] Associations of short-term PM2. 5 exposures with nasal oxidative stress, inflammation and lung function impairment and modification by GSTT1-null genotype …

B Sun, J Song, Y Wang, J Jiang, Z An, J Li… - Environmental …, 2021 - Elsevier
… a major urban air pollutant worldwide. Its effects on the respiratory system of the susceptible
… Finally, the interaction between GST genes and other antioxidant genes was not examined. …

Biomarkers for the adverse effects on respiratory system health associated with atmospheric particulate matter exposure

C Guo, S Lv, Y Liu, Y Li - Journal of Hazardous Materials, 2022 - Elsevier
… MDA in urine, serum or EBC was frequently monitored to reflect air pollution-derived
systemic or airway oxidative stress. Quite a few studies have proven the elevated MDA level in …

Polymorphisms in oxidative stress, metabolic detoxification, and immune function genes, maternal exposure to ambient air pollution, and risk of preterm birth in …

N Zhao, W Wu, Y Feng, F Yang, T Han, M Guo… - Environmental …, 2021 - Elsevier
… the interactive effects of maternal air pollution and genetic … the thoracic region of the respiratory
system. There are serious risks to … unbalanced ROS, damaged antioxidant defenses, and …

Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults

KE Cosselman, J Allen, KL Jansen, P Stapleton… - Environmental …, 2020 - Elsevier
… in antioxidant/stress response leukocyte gene expression (… significantly attenuated by the
selected antioxidant pre-treatment. … underlying the adverse effects of traffic-related air pollution. …

Protective effects of inhaled antioxidants against air pollution-induced pathological responses

KD Schichlein, GJ Smith, I Jaspers - Respiratory Research, 2023 - Springer
antioxidant levels in the airway surface liquid (ASL), providing protection against oxidative
damage from air pollution. … antioxidant gene HO-1 in the nasal mucosa. In the same study, the …

Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function

X Dai, SC Dharmage, CJ Lodge - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
… clinical features including airway inflammation and reversible airway … GST genes may
influence antioxidant function in the lungs and … Evidence for an interactive effect of GSTM1 on the …