… for IL-12 production and for protective immunity against … of IFN-γ because of a lack of stimulation
through the IL-12R. This … The patients with AR complete STAT-1 deficiency had multiple, …

… the CC/DB domain interface or the ND dimer interface block … that STAT-1 increases the levels
of both IL-12 and TNF-α in … this differentiation, IL-12 binds to the IL-12 receptor (IL-12R) and …

… of the IL-12-IFN-γ pathway was successful in identifying immune deficits … to the
Interleukin-12-Interferongamma (IL-12-IFN-γ) pathway, … Signal transduction through IL-12R firstly …

… of IL-12 and IFN-β by DC. At the early stage of infection, … receptor (IL-12R) complex, which
is composed of two chains: IL-… either of the two IFN-γR chains or STAT-1 is associated with the …

… expression of IL-12R and Interferon gamma receptor 1 (IFN-… evolution of a child with complete
IL-12 Rβ1 deficiency. CNS TB is … or any other cause of immunodeficiency such as MSMD. …

… [24] PEG conjugated to IFN-α at IFN/IFNR-binding interface … IL-12 binds to the IL-12 receptor
(IL-12R), which is expressed … T cell lymphoma, acquired immunodeficiency syndrome (AIDS)…

… a comprehensive study to examine not only the IL-12/IFN-γ axis, but also Th17/Treg cytokine
levels in patients with idiopathic PNTM disease through comparisons with CF and PCD …

… vigorous [4], as the described deficiencies in IL-12, IFN-γ or TNF pathways that lead to the
… In fact, defects in the IL-12-IFN-γ axis led to immune deficiency and intersect with the IFN-γ-…

… IFN-γ has been shown … , IL-12 and IL-23 are generally responsible for inducing RA.
Development of ustekinumab (Stelara), a humanized mAb that binds the shared p40 subunit of IL-12 …

… of the innate immune system, interferons provide an early … -JAK-STAT signaling can result
in immunodeficiency (25, 26). If the … IL-12 and IL-23 signaling sustains chronic inflammation by …