Interleukin-15 in autoimmunity

H Allard-Chamard, HK Mishra, M Nandi, M Mayhue… - Cytokine, 2020 - Elsevier
… IL-15 signaling in autoimmunity. Unlike therapies targeting other … of IL-15 signaling in
autoimmunity and explore potential … role of IL-15 in autoimmune diseases and the complexities of …

[HTML][HTML] Interleukin-15 (dys) regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer

TA Waldmann, MD Miljkovic, KC Conlon - Journal of Experimental …, 2020 - rupress.org
IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T, γδ, ILC1, and memory CD8
T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases …

Interleukin‐6 and interleukin15 as possible biomarkers of the risk of autoimmune diabetes development

K Siewko, R Maciulewski… - BioMed Research …, 2019 - Wiley Online Library
… was to assay circulating interleukin-15 (IL-15) and interleukin-6 (IL-6) levels and insulin
resistance measured by two different methods in newly diagnosed autoimmune diabetes (AD) …

Therapeutic potential of interleukin-15 in cancer

G Isvoranu, M Surcel… - Experimental and …, 2021 - spandidos-publications.com
… , being involved in the pathogenesis of several autoimmune diseases. IL-15 induces … IL-15
has been detected in patients with such autoimmune diseases as inflammatory bowel …

Interleukin-15 enhances proinflammatory T-cell responses in patients with MS and EAE

C Laurent, G Deblois, ML Clénet… - Neurology …, 2020 - AAN Enterprises
… We posit that interleukin-15 (IL-15) is a relevant contributor to MS … Interleukin-15 (IL-15)
is a potential contributing factor to the … in experimental autoimmune encephalomyelitis (EAE). …

[HTML][HTML] Elevated serum levels of interleukin-15 in pemphigus Vulgaris patients: A potential therapeutic target

M Kheirodin, Z Tehranchinia, Y Ketabi… - Dermatology Practical …, 2022 - ncbi.nlm.nih.gov
… (PV) is a rare autoimmune disease that causes painful blistering. Interleukin-15 (IL-15) as a
… with the development of the chronic inflammatory or autoimmune disease. There is not much …

Interleukin-15 as a biomarker candidate of rheumatoid arthritis development

W Kurowska, M Przygodzka, M Jakubaszek… - Journal of clinical …, 2020 - mdpi.com
interleukin-15 (IL-15) can serve as a new biomarker of RA development in patients with
undifferentiated arthritis (UA). Interleukin-15, … Interleukin-15 showed higher sensitivity (77.8%) …

Interleukin-15 is a hair follicle immune privilege guardian

T Suzuki, J Chéret, FS Dinelli, A Rajabi-Estarabadi… - … of Autoimmunity, 2024 - Elsevier
The autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key
pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) …

Counteracting interleukin-15 to elucidate its modes of action in physiology and pathology

E Mortier, M Maillasson, A Quéméner - Journal of Interferon & …, 2023 - liebertpub.com
… However, dysregulations of IL-15 expression could occur and participate in the emergence
of autoimmune inflammatory diseases as well as hematological malignancies. It is therefore …

Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes

N Skariah, OJ James, M Swamy - Discovery Immunology, 2024 - academic.oup.com
… of cytokine interleukin-15—at low levels, it is required for the homeostasis of the immune
system, yet when it is upregulated in response to pathogenic infections or in autoimmunity, IL-…