[HTML][HTML] … levels of cerebrospinal fluid kappa free light chains relate to IgM intrathecal synthesis and might have prognostic implications in relapsing multiple sclerosis

J Castillo-Villalba, S Gil-Perotín… - Frontiers in …, 2022 - frontiersin.org
… tool to OCGBs and as a risk factor for neurological disability and treatment failure. … to
progressive disease and long-term disability in MS (24). Comabella et al. showed a correlation

Predicting aggressive multiple sclerosis with intrathecal IgM synthesis among patients with a clinically isolated syndrome

E Monreal, S Sainz de la Maza… - Neurology …, 2021 - AAN Enterprises
disability milestones, in contrast to OCMB and IgM index. However, LS-OCMB provided a
2-fold significantly higher sensitivity than Reibergram, even if these results are probably …

Prognostic role of intrathecal IgM synthesis in multiple sclerosis: Results from a clinical series

M Fonderico, T Biagioli, L Lanzilao… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Disability Status Scale, IgG oligoclonal bands and disease-… and infectious diseases of the
central nervous system (CNS), … 13% 21 without any correlation with disability and inflammatory …

Association of intrathecal immunoglobulin G synthesis with disability worsening in multiple sclerosis

C Gasperi, A Salmen, G Antony, A Bayas… - … neurology, 2019 - jamanetwork.com
… of patients with MS in this study (IgA, 22%; IgM, 9%). Intrathecal IgM synthesis has previously
… To our knowledge, a correlation of intrathecal IgA synthesis with disease course has been …

Intrathecal immunoglobulin M synthesis is an independent biomarker for higher disease activity and severity in multiple sclerosis

…, for the Swiss Multiple Sclerosis Cohort Study - … of neurology, 2021 - Wiley Online Library
… Additionally, we demonstrate that the presence of intrathecal IgM production is associated
with a … In contrast, intrathecal IgM synthesis and its relation to treatment effects have not been …

Intrathecal IgM as a prognostic marker in multiple sclerosis

MT Mailand, JL Frederiksen - Molecular diagnosis & therapy, 2020 - Springer
nervous system (CNS). As the symptoms and course of the … was found to be a negative
predictor of long-term disability … , a moderate negative correlation was found between IgM loc …

Intrathecal IgM synthesis is associated with spinal cord manifestation and neuronal injury in early MS

…, J Kuhle, for the Swiss MS Cohort Study - … of neurology, 2022 - Wiley Online Library
MS, 8 even when asymptomatic they appear to be the strongest MRI predictor of physical
disability … of Ig subtypes is not evenly and independently distributed and to analyze it in relation

Decoding intrathecal immunoglobulins and B cells in the CNS: their synthesis, function, and regulation: Modulation of immune responses mediated by different B cells …

N Negi, BK Das - International Reviews of Immunology, 2020 - Taylor & Francis
correlation between intrathecal production of IgM and early onset of MS and reported that
intrathecal production of IgM … of intrathecal IgG synthesis with expanded disability status scale (…

Intrathecal IgM production is a strong risk factor for early conversion to multiple sclerosis

C Pfuhl, U Grittner, RM Gieß, M Scheel, JR Behrens… - Neurology, 2019 - AAN Enterprises
… and medical history, Expanded Disability Status Scale (EDSS) … the concentration of locally
synthesized intrathecal IgG in CSF (… In further group comparisons and Spearman correlation

Prognostic value of intrathecal IgM synthesis determined by various laboratory methods in patients with early multiple sclerosis-a prospective observational study

K Revendova, D Zeman, P Kusnierova… - Multiple Sclerosis and …, 2022 - Elsevier
disability in patients after the first demyelinating event of MS. … of Neurology, University
Hospital Ostrava, Czech Republic. … Correlation of individual methods for determining intrathecal