… Structural analyses of ferroportin indicate that there are two divalent metal-binding sites, …
the ubiquitination of the lysine-rich cytoplasmic segment connecting the two 6-helix domains of …

… the iron efflux from cells [2]. Hepcidin itself does not bind iron but has two distinct metal-binding
sites with a potentially high affinity for other metal ions. One of these sites is its N-terminal …

… findings in iron biology, deregulation of the hepcidin-ferroportin axis in iron disorders and how
… The metal transporter DMT1 takes up ferrous iron, reduced by DCYTB, on the luminal side …

… apical membrane via divalent metal transporter 1 (DMT1), … significant role of hepcidin in
the iron homeostasis and as an … with a rare vicinal disulfide connection at Cys 4 –Cys 5 [23]. …

… As a transition metal with two major biological oxidation states, iron is also … hepcidin synthesis
in response to inflammatory cytokines. Our laboratory recently demonstrated that hepcidin …

… metal irons such as zinc upregulate hepcidin gene transcription via interactions between
functional metal response elements (MREs) in the hepcidin … HCV NS5A reduces hepcidin gene …

… degradation, hepcidin decreases the amount of iron in the … the indirect influence of hepcidin
on the divalent metal transporter 1 (… Its antimicrobial properties are tightly connected with iron …

… Iron is an essential trace metal involved in oxygen transport, cellular metabolism, DNA …
of how iron homeostasis and hepcidin are regulated and the signaling pathways involved. …

… of the therapeutic potential of hepcidin in iron-associated … .92, 98-101 The connection between
the mutations in other genes … of brain iron metabolism, hepcidin, metal transport proteins, …

… Links between iron metabolism and other metals being suggested, our aim was to … elements
underline that potential iron - other metal metabolism inter-connections could play a role in …