… The existing evidence suggests no added survival benefit … Overall, a random-effects analysis
of β-lactam/aminoglycoside … or did not receive a short course of gentamicin administered as …

… The insights gained from these large, early clinical trials add considerable value and a
clinical perspective to the future design, optimization, and implementation of innovative DBL that …

… demonstrate beneficial effects of a short-course of aminoglycosides added to β-lactam
antibiotics on 30-day mortality … and uncertainty about its benefits, a randomized trial is warranted. …

… A random intercept linear mixed model was used to evaluate … the addition of aminoglycosides
to β-lactam antibiotics in the … concluding that the addition of an aminoglycoside did not …

… Simultaneously, extending the dose intervals of aminoglycosides might … Although randomized
controlled trials on TDM and … In addition, TDM helps monitor PK target attainment and …

… in two phase III randomized controlled trials. The EPIC … I, II, and III clinical trials in addition
to other PK studies. The most … the superiority over β-lactam-based therapy in the EPIC trial, a …

… In trials spanning 35 years, neither the addition of an aminoglycoside for S aureus endocarditis
18 nor of rifampicin for S aureus bacteremia 19 resulted in improved clinical outcomes; …

… Nevertheless, most of the randomized clinical trials (RCT) … once-daily dosing regimen and
in a short course (13, 23). As reported in … In addition to choosing the optimal empirical β-lactam …

… of data in treating CRE infections in randomized controlled trials, these data, taken with in …
to the antibiotic and during active treatment. Aminoglycosides have been utilized as add-on …

… Of those we tested the efficacy of combinations of 2 common β-lactam antibiotics … Added
value of this study … In this study, we aimed to characterize the antibiotic interaction profiles in vitro …