… p=0.012), while a trend in favor of the lack of surgery on primary tumor was observed in
G13D mutation (1-sided p=… hotspots mutation of KRAS with the remaining overall KRAS-mutated …

… Although the predictive effect of KRAS mutations on EGFR … OS and PFS, but not other tumors
with KRAS mutations. A meta-… therapy in KRAS G13D and other KRAS-mutated metastatic …

… the proven predictive significance of KRAS mutations in CRC … % of RAS-mutated patients
were KRAS mutants, with G12D … mutations were G12D (33.1%), G12V (21.2%) and G13D (16.7…

… mutant KRAS is a negative prognostic factor and that p.G12C/… G12C variant predicted shorter
survival (HR: 2.26, p = 0.001) … G13D KRAS mutation had better survival. In this light, it was …

… subtypes (G12A, G12R, G12S, G13C and G13D) were also found in the BEV group. … the
clinical relevance of KRAS mutations, we performed comparative statistical analyses of KRAS …

… G13D). Não foi encontrada correlação entre a mutação KRAS ea idade (p=0,646) ou o
gênero (p… The KRAS mutation is a predictor of a negative response to treatment with EGFR …

… This study aims to determine the prevalence of specific KRAS mutations and their … mutations
occurred in the P-loop region (codons 12 and 13, 91.3% of cases); G12D, G12V and G13D …

… yielded a good prediction of those KRAS codon 12 mutations truly … mutation was much less
prevalent than predicted from … In our prospectively acquired cohorts, KRAS G13D exhibited a …

… , P < 0.05), but not second-line chemotherapies. CONCLUSION: The KRAS G12C mutation
could be a predictive … Other identified KRAS mutations included G12S, G12R, G13C, G13D, …

… on the surface or in the core of KRAS that are predicted to … of therapeutic strategies across
mutants of the same class. For … cancers harboring G13D, but not Gly12, mutants of KRAS (99). …