Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system

JA Petrocchi, DL de Almeida, P Paiva-Lima… - European journal of …, 2019 - Elsevier
… stimuli was measured in Swiss mice using the Randall and … ketamine in activating the
neuronal nitric oxide synthase (nNOS) enzyme to produce antinociception via the L-arginine/nitric

Participation of the cannabinoid system and the NO/cGMP/KATP pathway in serotonin-induced peripheral antinociception

DD Aguiar, JA Petrocchi, GC da Silva, VS Lemos… - Neuroscience …, 2024 - Elsevier
… the paw of mice. Taken together, these data suggest that the … is related to the activation of
the nitric oxide/cyclic guanosine … intraperitoneal injection of 10 % ketamine (Cayman Chemical) …

Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation …

DL de Almeida, RCM Ferreira, FC Fonseca… - Nitric Oxide, 2024 - Elsevier
… In this procedure, animals were first anesthetized with a 10% ketamine hydrochloride … the
peripheral tissues and how that nitric oxide affects the CDB-mediated antinociception observed …

Nitric oxide and potassium channels but not opioid and cannabinoid receptors mediate tramadol-induced peripheral antinociception in rat model of paw pressure …

RR Soares-Santos, DP Machado… - Canadian Journal of …, 2023 - cdnsciencepub.com
… intraperitoneal injection of anesthetic (300 mg/kg ketamine … not activate peripheral opioid
receptors, we propose that it … of the nitric oxide-cyclic GMP pathway, Eur. J. Pharmacol. …

Ketamine Anesthesia on Neurocyte in Fetal Rat via cAMP and NO/cGMP Pathway.

Y Chen, W Liu, M Liu, J Zhao, X Li… - Pakistan Veterinary …, 2019 - search.ebscohost.com
… to increase intracellular cyclic adenosine monophosphate (cAMP) (… NO synthase to induce
peripheral antinociceptive effects (… the activation of α2-adrenoceptor-mediated pathways and …

[HTML][HTML] Anti-allodynic effect induced by curcumin in neuropathic rat is mediated through the NO-cyclic-GMP-ATP sensitive K+ channels pathway

T Pastrana-Quintos, G Salgado-Moreno… - … medicine and therapies, 2020 - Springer
… that drugs which activate the NO-cGMP pathway seem to … Rats were anesthetized with a
mixture of Ketamine (45 mg/kg… the opening of K + channels induces anti-nociception [36, 40]. In …

Artemisia biennis Willd.: Anti-Nociceptive effects and possible mechanisms of action

M Zarei, D Ahmadimoghaddam… - Journal of …, 2021 - Elsevier
… Animals were anesthetized with ketamine (60 mg/kg), xylazine (6 mg/kg), and … on
ABAEO-induced peripheral antinociception during the early phase in Swiss mice formalin induced

[HTML][HTML] Narrative review: low-dose ketamine for Pain Management

A Riccardi, M Guarino, S Serra… - Journal of Clinical …, 2023 - mdpi.com
… by ketamine appears to disinhibit pyramidal neurons, activate … action of ketamine on sodium
channels at peripheral nerve … In rats, the lethal dose of ketamine is well above 40 mg/kg [45]…

[HTML][HTML] Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors …

ZA Zakaria, MH Abdul Rahim, MH Mohd Sani… - … and alternative medicine, 2019 - Springer
… and larginine/nitric oxide/cyclic-guanosine monophosphate … anesthetized with 60 mg/kg
ketamine plus 7.5 mg/kg xylazine … on larginine/nitric oxide/cyclic guanosine monophosphate (l…

[HTML][HTML] … /morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways

AF Bedair, A Wahid, NS El-Mezayen… - Biomedicine & …, 2023 - Elsevier
… as NO and cyclic guanosine monophosphate (cGMP) are also … by several drugs including
morphine, diclofenac, ketamine, … abrogate the antinociception indicated that GC is activated by …