Ketogenic Diet, Circadian Rhythm and Aging

A Jagota, SA Sharma - Nutrition, Food and Diet in Ageing and Longevity, 2021 - Springer
… population of neuronal circadian oscillators perceives the … Fasting induces ketogenic genes
under regulation of mTOR–… acid synthesis pathways, whereas PPARα target genes were up …

[HTML][HTML] Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice

R Nakao, T Abe, S Yamamoto, K Oishi - Scientific Reports, 2019 - nature.com
Ketogenic diets (KD) that are very high in fat and low in carbohydrates are thought to …
underlying mechanisms of muscle wasting induced by chronic starvation. This diet decreased the …

Molecular regulation of brain metabolism underlying circadian epilepsy

F Chan, J Liu - Epilepsia, 2021 - Wiley Online Library
Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway
that might be involved in muscle thermogenesis. Sci Rep. 2017;7:2885. …

Dietary factors in circadian rhythm modulation and their impact on metabolic diseases: a state of the science review

M Dalvi, S Medithi - Biological Rhythm Research, 2024 - Taylor & Francis
… In KD-fed mice, Slc25a25, associated with thermogenesis, … In summary, the ketogenic diet,
initially designed for childhood … pathway plays a role in the Bmal1 phase shift induced by a …

A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes

H Zhuang, Y Fujikura, N Ohkura… - Food Research …, 2023 - Elsevier
… tissues, and skeletal muscle were almost identical between the … ketone bodies without
inducing carbohydrate starvation on … ketone bodies modulate neuronal functions in the central …

Temporal response to bioenergetic stress in adipose tissue and skeletal muscle

L Pendergrast - 2024 - openarchive.ki.se
… We observed that core clock genes Neuronal PAS domain … role of circadian function in the
regulation of skeletal muscle lipid … This study also shows that the early active phase induces a …

[HTML][HTML] Ketogenic Diet Affects Sleep Architecture in C57BL/6J Wild Type and Fragile X Mice

PR Westmark, AK Gholston, TJ Swietlik… - International Journal of …, 2023 - mdpi.com
… Treatment with a ketogenic diet flattened diurnal sleep … for weight loss and is being tested in
numerous neurological models [19… physiological and metabolic pathways. The importance of …

[HTML][HTML] A low-carbohydrate ketogenic diet and treadmill training enhanced fatty acid oxidation capacity but did not enhance maximal exercise capacity in mice

S Ma, J Yang, T Tominaga, C Liu, K Suzuki - Nutrients, 2021 - mdpi.com
… advise us to eat in compliance with our circadian clock [4]. … Nakao et al. reported that an
LCKD induced Slc25a25, an ATP … that the response of liver metabolic pathways to the KD and …

Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body …

H Okauchi, S Higo-Yamamoto, T Sowa, H Oike… - Biochemical and …, 2020 - Elsevier
… We also examined the effects of SB on circadian rhythms of locomotor … muscle at ZT14
under SB, and this might be involved in the SB-induced decrease in CBT, because Slc25a25

[HTML][HTML] The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

DJ Ham, A Börsch, S Lin, M Thürkauf… - Nature …, 2020 - nature.com
… , we used nerve-muscle preparations of the SOL muscle to … -induced muscle wasting in C2C12
myotubes, genes associated … exacerbates the latter pathway in specific muscles, indicates …