… LINE-1, Alu, and SVA elements in the genome of patient tumors with colorectal advanced
adenomas. … LINE-1 hypomethylation status was evaluated by absolute quantitative analysis of …

… relationships between LINE-1 hypomethylation, copy … LINE-1 hypomethylation can contribute
to the acquisition of aggressive tumor behavior through LINE-1 retrotransposition and tumor…

… cancer normal tissues obtained from oral cancer patients. We observed increased
hypomethylation of L1- promoter in cancer tissues … samples showed a detectable level of L1 …

… determine the hypomethylation of canine LINE-1 in liquid biopsies for canine mammary
tumors (CMT) and to assess its diagnostic performance in human plasma. BC associated LINE-1 …

… We detected a statistically significant L1PA 15 hypomethylation in cfDNA of metastatic
colorectal cancer (CRC M+), breast cancer (BRC M+) and uveal melanoma (UVM M+) samples as …

… As tumor DNA hypomethylation and NOS2 expression are both associated with aggressive
cancer phenotypes and poor survival rates among patients, we investigated the role of NOS2 …

… detect common cancer-specific signatures in blood. We targeted hypomethylation of LINE-1 …
-based targeted bisulfite method coupled to deep sequencing, together with computational …

… Significance: This study demonstrated that LINE-1 hypomethylation … levels were observed
in knee OA patients. Collectively, … of tissue-specific tumor cells in patients with musculoskeletal …

… unmethylated LINE-1 levels than healthy donor serum 60 . Similarly, LINE-1 hypomethylation
of plasma cfDNA was proposed as a disease progression biomarker for colorectal cancer …

… In this work, we hypothesized that LINE-1 methylation levels … regions corresponding to the
10 LINE-1 array probes that had … encompassing lung cancer (cfDNA n = 167; tissue n = 137; …