… the apolipoprotein E polymorphism and the kringle-IV repeat polymorphism of the LPA
gene … the commonly assumed inverse relationship between apo(a) isoform size and Lp(a) …

… and LPA Kringle IV type 2 (KIV-2) size polymorphism in … between Lp(a) plasma levels, LPA
KIV-2 size polymorphism, reflecting a variable number of kringle (K) IV type 2 apolipoprotein (…

… of varying size, apolipoprotein(a), covalently bound. … variation in the apolipoprotein(a)-coding
LPA gene, may vary … in 70 286, LPA kringle-IV type 2 (KIV-2) number of repeats genotype …

… (a), LPA kringle-IV type 2 (KIV-2) number of repeats, and LPA … , the kringle IV-2 repeats, which
give rise to size heterogeneity… quantitation of apo(a) independent of its size polymorphism. …

… apolipoprotein(a) that included 455 patients. Common … low number of Kringle IV type 2 (KIV
2 ) repeats, which translate … -base polymorphisms in the hypervariable LPA kringle IV type 2 …

… LPA encodes for apolipoprotein(a) [apo(a)], which consists of 10 different kringle IV domains
(KIV-… variation (KIV-2 repeat), which leads to >40 apo(a) protein isoforms in the population ( …

… structural domains called kringles, with multiple copies of kringle IV (… sized apo(a) proteins
are encoded by differently sized LPA … A polymorphism (−174G/C) in the promoter of the gene …

… kringle IV type 2 (KIV-2) domain is further expanded resulting in a multiallelic, intragenic
copy number variation (from 1 to 40 repeat … that the LPA gene is extremely polymorphic but …

… polymorphism carriers. The study of Lee et al. , showed that the LPA SNPs was associated
with the size of apolipoprotein … of repeats. The other study including that identified SNPs in the …

… apo(a) isoform is induced by the different numbers of kringle IV type-2 (KIV-2) repeats in the
LPA gene… results by detecting the same polymorphism in the KIV repeat domain of apo(a) [40…