Label-Free Interference Imaging of Intracellular Trafficking

JS Park, IB Lee, SC Hong, M Cho - Accounts of Chemical …, 2024 - ACS Publications
… (2) This paper presents real-time, label-free observations that … and track nanoparticles
through ultrahigh-speed imaging in … 3D nanoarchitecture of cellular adhesions that connect the …

Label-Free, Ultrahigh-Speed, Direct Imaging and Tracking of Bionanoparticles in Live Cells by Using Coherent Brightfield Microscopy

CL Hsieh - Label-Free Super-Resolution Microscopy, 2019 - Springer
… should be sufficient for direct observation and dynamic study. … , as well as bidirectional
and correlated motions. These two … to probe intracellular dynamics in their native condition. …

Label-free dynamic imaging of chromatin in live cell nuclei by high-speed scattering-based interference microscopy

YT Hsiao, CN Tsai, TH Chen, CL Hsieh - ACS nano, 2021 - ACS Publications
… is more suitable for intracellular imaging because COBRI … Our result of high correlation
between the Vd map and the … that the light dose for our observation did not affect the nuclear …

Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment

JS Park, IB Lee, HM Moon, SC Hong, M Cho - Nature communications, 2023 - nature.com
… Our label-free, cargo-tracing method revealed not only the … Here, we report the universal
feature of intracellular traffic flow, … in a highly coherent and correlated manner, suggesting that …

Molecularly specific and functional live cell imaging by label-free interference microscopy

YT Hsiao, CN Tsai, CY Cheng, CL Hsieh - ACS Photonics, 2022 - ACS Publications
… The high correlation between the RI map and the fluorescence image (Figure 1c) … a map of
active intracellular transportation. A large number of observations are required for creating an …

Roadmap on LabelFree Super‐Resolution Imaging

VN Astratov, YB Sahel, YC Eldar… - Laser & Photonics …, 2023 - Wiley Online Library
… based on quantum photon correlation allows increasing the … We recently observed that the
scattering of topologically struc… report on cell growth and intercellular mass transport with very …

Spatiotemporal three-dimensional transport dynamics of endocytic cargos and their physical regulations in cells

C Jiang, M Yang, W Li, SX Dou, PY Wang, H Li - Iscience, 2022 - cell.com
… Strikingly, inside the vesicles, we observed endocytic … for the intracellular transport in
three-dimensional (3D) cells. For … correlated with the timescales. Therefore, characterizing the …

Long-term cellular cargo tracking reveals intricate trafficking through active cytoskeletal networks

JS Park, IB Lee, HM Moon, SC Hong, M Cho - bioRxiv, 2022 - biorxiv.org
… of motor vehicles in busy two-way roads. Other cytoplasmic … Our experimental observations
strongly support the recent … the locations of intracellular cargos by using label-free iSCAT …

High-precision protein-tracking with interferometric scattering microscopy

RW Taylor, C Holler, RG Mahmoodabadi… - Frontiers in Cell and …, 2020 - frontiersin.org
… or boundary is encountered no correlation in steps would be … most likely trapped in an
intracellular vesicle, the inspection … biology, with aims ranging from label-free detection and mass-…

Small stepping motion of processive dynein revealed by load-free high-speed single-particle tracking

J Ando, T Shima, R Kanazawa, R Shimo-Kon… - Scientific reports, 2020 - nature.com
… size at low [ATP] may correlate with regulatory roles of AAA3 … from the microtubule were not
observed. The next important … In this study, we have successfully observed stepping motion …