… extremely advantageous properties of microbial metabolites. … of lactacystin, that when we
do find some novel chemicals, we … The lactacystin-induced DA cell death is probably apoptotic …

… Another example of microbial secondary metabolites that … inhibitor was the microbial secondary
metabolite lactacystin [17]. … FR901228, a novel antitumor bicyclic depsipeptide produced …

… and interact synergistically with other conventional and novel … product of the microbial
metabolite lactacystin, was isolated … inhibited cell growth and induced G0/G1 cell cycle arrest with …

… that inhibit the activity of AChE in order to create novel … of lactacystin apparently involves
amine acylation [38], we envisioned that related active esters could also induce neuritogenesis. …

… , lactacystin, was serendipitously identified in extracts of Streptomyces in a screen for the
induction of neurites in a neuroblastoma cell … A novel orally active proteasome inhibitor induces …

… Norrish reactions are important photo-induced … mode of biological action disclosed that
lactacystin (86) inhibits the … Photochemistry serves as an effective tool for mastering novel and …

… We recently looked for novel compounds having anti-… by antigen specific IgE that causes
mast cell degranulation [31], … Compared with bortezomib and lactacystin, salinosporamide A …

… [47,51] and neuroblastoma cells by a pathway like iron … )-positive neurons induced by
post-intranigral injection of lactacystin (… Considering the neuritogenic effect of M30 demonstrated …

… metabolites from marine-derived bacteria represent a rich source for drug development with
novel … prevent apoptosis and necrosis induced by H 2 O 2 in neurons and glial cells [12]. In …

… Microbial metabolites have provided a wealth of proteasome inhibitors (Fig. 1). Lactacystin
… , 3,4 after observations that it induced differentiation of the mouse neuroblastoma cell line, a …