Unique genomic landscape of high-grade neuroendocrine cervical carcinoma: implications for rethinking current treatment paradigms
RN Eskander, J Elvin, L Gay, JS Ross… - JCO Precision …, 2020 - ascopubs.org
… to allow for comparison of genomic alterations (GAs). The submitting physicians provided
specification of a poorly differentiated, neuroendocrine tumor type of cervical origin, which was …
specification of a poorly differentiated, neuroendocrine tumor type of cervical origin, which was …
[HTML][HTML] Clinical and genetic landscape of treatment naive cervical cancer: alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome
S Scholl, M Popovic, A de La Rochefordiere, E Girard… - …, 2019 - thelancet.com
… may improve outcome in subsets of cervical cancer patients. … The etiology of >90% of cervical
cancers is the persistent … to genomic instability and accumulation of molecular alterations. …
cancers is the persistent … to genomic instability and accumulation of molecular alterations. …
Molecular landscape of recurrent cervical cancer
Cervical cancer (CC) is a major gynecological problem in developing and underdeveloped
countries. Despite the significant advancement in early detection and treatment modalities, …
countries. Despite the significant advancement in early detection and treatment modalities, …
Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning
J Huang, Z Qian, Y Gong, Y Wang, Y Guan… - Journal of medical …, 2019 - jmg.bmj.com
… and used to define the genomic landscape in CC and to find … of genomic alterations and HPV
integrations in normal cervical … to combine cellular genomic alterations and virus integration …
integrations in normal cervical … to combine cellular genomic alterations and virus integration …
The immune landscape during the tumorigenesis of cervical cancer
Y Wang, M He, G Zhang, K Cao, M Yang… - Cancer …, 2021 - Wiley Online Library
… As a result, we revealed cervical diseases develop molecular traits and evasive
mechanisms while progressing. Our findings provide a landscape of the interactions between …
mechanisms while progressing. Our findings provide a landscape of the interactions between …
[HTML][HTML] … of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma
… in the HPV-independent tumors was performed in 15 samples, which showed that the
mutations with highest cancer cell fraction (likely being the initial genomic alteration) were TERT …
mutations with highest cancer cell fraction (likely being the initial genomic alteration) were TERT …
[HTML][HTML] Identification of potential driver genes based on multi-genomic data in cervical cancer
Y Xu, H Luo, Q Hu, H Zhu - Frontiers in Genetics, 2021 - frontiersin.org
… ; depicted a comprehensive genomic landscape of cervical cancer; performed molecular …
cervical cancer genome alterations, tissue specimens were analyzed by multiple genomic …
cervical cancer genome alterations, tissue specimens were analyzed by multiple genomic …
Genomic characterization of cervical cancer based on human papillomavirus status
L Zhang, Y Jiang, X Lu, H Zhao, C Chen, Y Wang… - Gynecologic …, 2019 - Elsevier
… clinical information of 299 cervical cancer patients as the first … analyses to characterize this
tumor based on HPV status, … landscapes were compared between multiple tumor cohorts …
tumor based on HPV status, … landscapes were compared between multiple tumor cohorts …
Genomic alterations in STK11 can predict clinical outcomes in cervical cancer patients
S Hirose, N Murakami, K Takahashi, I Kuno… - Gynecologic …, 2020 - Elsevier
… Additionally, the association between genomic alterations … the genomic alteration profiles
of 154 Japanese cervical cancer … the association between genomic alterations and clinico-…
of 154 Japanese cervical cancer … the association between genomic alterations and clinico-…
[HTML][HTML] The landscape of somatic copy number alterations in head and neck squamous cell carcinoma
J Yang, Y Chen, H Luo, H Cai - Frontiers in Oncology, 2020 - frontiersin.org
… In our collections, the genomic alterations ranged from whole arm gains and losses to focal
high-level amplifications. The mean size of the CNAs was 6.7 Mb, and the average number …
high-level amplifications. The mean size of the CNAs was 6.7 Mb, and the average number …