… hypothesis testing and discovery in the pharmacogenomics field, … In conclusion, dependency
on ITGB3 was considered to be one … may be of great benefit to drug development and drug …

… We used time-dependent area under the curve (AUC) and decision curve analyses to …
Pan-cancer DNA methylation analysis revealed that ITGB3 was the most common hypomethylated …

… However, the metastatic effects of ITGB3 and ITG8 in OC require further research. … ITGB3
promotes cisplatin resistance in osteosarcoma [86] and is abundant in both drug resistance and …

… beta 3 (ITGB3) was identified as a target to overcome chemoresistance in mesenchymal
lung cancer, and inhibition of ITGB3 sensitizes cancer cells to chemotherapy by regulating the …

… is dependent not only … ITGB3 on MM cells [45]. Our data indicated that targeting EGFL7
using neutralizing antibodies or ITGB3 using an integrin inhibitor could override drug resistance …

… Nevertheless, drug resistance is still a major problem in most cancer therapies. Epithelial-…
pharmacogenomics will help to figure out the biological impact of the EMT on drug resistance …

… in the early stages, patients carrying ITGB3 rs5918 TT genotype had a reduced survival …
with a higher insensitivity to platinum-based first-line chemotherapy, likely due to its role in …

… Well-adapted to large-scale tissue culture, established cell lines … for ITGB3 upregulation,
the U87MG and T98G FDA drug … by chemical biology is always dependent on the quality and …

… that ITGB3 has a close relationship with drug resistance [48-… necrotic cell-induced and
ATP-dependent manner [72]. As we … have been validated by large scale cohort studies and …

… individual clinical treatment and drug development and also provided the basis for the
inclusion and exclusion criteria of the population for clinical trials of new targeted drugs. In the …