… leptin-mediated signaling via the JAK2–STAT3 pathway to prevent obesity. LepRb signaling
is … regulators of leptin signaling: SOCS3 and PTP1B. SOCS3 expression is enhanced by …

… Considering the implication of negative regulators of leptin signaling, the use of SOCS3
and PTP1B inhibitors represents an interesting option for use in restoring leptin response. …

… in which resistin downregulates leptin signaling. Potential physiological consequences of …
on leptin signaling favors the development of hyperinsulinemia to overcome insulin resistance …

… Notably, constitutive activation of hypothalamic IKKβ impairs leptin signalling and increases
weight gain and food intake, while genetic or pharmacological inhibition of IKKβ activity …

… leptin signalling by coupling to ERK kinase, all of the other four phosphatases work by inhibiting
leptin signalling, leading to leptin resistance [78]… shown to promote leptin resistance [79]. …

… SOCS3 inhibits the JAK2/STAT3 pathway by interacting with phospho-Y985 or JAK2 and
acting as a feedback inhibitor of leptin signaling. PTP1B also inhibits leptin signaling through …

… Tyr1138-STAT3 signaling also induces transcription initiation of target genes such as Socs3,
an important inhibitor of leptin signaling pathway. SOCS3 in turn blocks leptin signaling by …

… leptin levels acutely restores leptin signaling, which leads to enhanced leptin signaling during
a period of reduced leptin … This fall in leptin levels, which is acutely out of proportion to fat …

… promote leptin resistance. This review discusses the potential mechanisms that enable leptin
to … function in the contexts of healthy leptin signalling and of diet-induced leptin resistance. …

… Leptin binding to its receptor promotes various signal transduction pathways. After the binding
process, the leptin … , which is an important event for leptin signaling and activation of the …