… extent to which IDH mutations result in focal methylation changes by … mutations in DNMT3A
or TET2 were excluded from this analysis given their established hypomethylation phenotype …

… Initial cytogenetic studies in leukaemia identified chromosomal … marks in the genome creating
a synthetically lethal phenotype … methylation of DNA (ie, DNMT3A, IDH1, IDH1, TET2) or …

… Natural Killer (NK) cells play a role in the anti-leukemic … mutations in the TET2 gene are
characterised by phenotypic defects … whether TET2 mutations in NK cells could interfere with the …

… that mutations in TET2 are LOF mutations and that TET2 … In myeloid leukemias, mutations
in the IDH1 or IDH2 genes are … hypermethylation phenotype similar to that observed in IDH1/2-…

… driver genes within this large number of leukaemia associated disrupted genes. A small
fraction of … in TET2loss-of-function mutations. These changes in the epigenetic profile result in …

… of the cancer phenotype and may be attractive drug targets 2,3 . … patients display increased
promoter methylation and … it is likely that protein function is disrupted, including DNA/histone …

… Targeting founder TET2 MT could disrupt clonal proliferation at … than overt leukemia, we used
a human TET2 −/− leukemia cell … to TET2 increases C→T transition and mutator phenotype …

… differ from TET2 loss-of-function, by performing phenotypic, … The above results suggested
that Idh2 R172K disrupts hematopoietic … from leukemic clones that retain IDH1/2 mutations and …

… mutations in genes related to methylation, more specifically: … phenotype of AML is associated
with TET2/IDH1/2/WT1 … that the TET2, RUNX1, SPI1, NPM1 complex is disrupted by mutant …

… In acute myeloid leukemia (AML) TET2 mutations have been … that mutations in WT1 are
associated with similar methylation … offer a phenotype similar to that of TET2 mutations. Further, …