… scientists of the day on the thermodynamics of heme protein ligand binding reactions. Abel
had a deep interest in hemoglobin and discussions with him on the latest papers from Rome …

… on sickle cell disease has had a … sickle cell anemia is not only the first human disease to
be understood at a molecular level (the first molecular disease) (2, 3), it is also the first disease …

… Sickle cell anemia is a genetic disease associated with the polymerization of the deoxygenated
hemoglobin mutant, HbS, which differs from normal adult HbA by a single amino acid, …

… The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity
… of hemoglobin S (HbS). Treatment of sickle cell patients with voxelotor increases Hb levels …

… the lack of structural data of the HbS−ligand complexes. Interestingly, at least two of these
… The effect of beta 73 asparagine on the gelation and crystallization of hemoglobin. J. Mol. …

… Valeresol showed that these compounds bind to Hb in 2:1 ratio, … ’s original finding that Hb
binds two molecules of aromatic … candidates targeting Hb for sickle cell disease drug discovery…

… the kinetics of structural and ligand-binding events on time … states due to discrete ligand
binding and dissociation events, … specification of rates for ligand binding and dissociation within …

… sickle cell anemia patients with prior ethical committee approval was obtained from the Sickle
Cell … , along with an APO system without the ligand (alizarin): Hb S–APO. The respective …

… the ligand state of the molecule increases mean cell hemoglobin … In sickle cell anemia part
of the protective effect of HbF on … There is a pre-gelation lag phase that is similar to the delay …

… TRL4 is expressed on monocytes and macrophages and its ligand, lipopolysaccharide (LPS), …
Hydroxyurea increases total and fetal hemoglobin in SCD, thus reducing gelation and …