Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells

J Höfle, T Trenkner, N Kleist, V Schwane, S Vollmers… - EMBO …, 2022 - embopress.org
… functions in human NK cells independent of receptor-mediated induction of apoptosis. Direct
… which HIV-1 may not be able to prevent through immune evasion mechanisms. Therefore, …

Caspase-8 restricts natural killer cell accumulation during MCMV Infection

Y Feng, LP Daley-Bauer, L Roback, M Potempa… - Medical microbiology …, 2019 - Springer
… excess tissue damage while preventing acute and chronic … that initiates extrinsic apoptosis
and prevents receptor interacting … in NF-κB activation following CD16 or 2B4 ligation. Whether …

Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation

CC Cubitt, P Wong, HK Dorando… - The Journal of …, 2024 - Am Soc Clin Investig
… Further, we define a functional role for CD8α in regulating human NK cell activation. …
Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and …

Cytotoxic T lymphocytes and natural killer cells

SL Nutt, ND Huntington - Clinical Immunology, 2019 - Elsevier
Ligation of ITIM-containing receptors causes tyrosine phosphorylation and the … to prevent
self-reactivity by NK cells by binding to MHC class I molecules. The function of the activating

PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade

MP Trefny, M Kaiser, MA Stanczak, P Herzig… - Cancer Immunology …, 2020 - Springer
Natural killer cells, a subset of innate lymphoid cells, … cells through perforin and granzymes
[16] and/or the ligation … inhibit NK cell activation to prevent the destruction of nontransformed …

Caspase-8-dependent control of NK-and T cell responses during cytomegalovirus infection

Y Feng, LP Daley-Bauer, ES Mocarski - Medical Microbiology and …, 2019 - Springer
… into effector cells subsets [34] influenced by levels of killer cell … Receptor ligation results in
tyrosine phosphorylation of ITIM … Thus, T cell and NK cell activation induces a similar signaling …

[HTML][HTML] Natural killer cells induce HIV-1 latency reversal after treatment with pan-caspase inhibitors

J Furtado Milão, L Love, G Gourgi… - Frontiers in …, 2022 - frontiersin.org
… The presence of Z-VAD-FMK prevented cell death of J-Lat cells induced by KHYG-1 cells
(… an LTR-bound zinc finger protein through a proximity ligation assay. Although the parental …

[HTML][HTML] Optimizing NK-92 serial killers: Gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy

L Navarrete-Galvan, M Guglielmo… - Journal of Translational …, 2022 - Springer
… proliferation was prevented and cytolytic activity was substantially … cell death induced after
ligation of cellular Fas/CD95, NK-92 or Jurkat cells were cultured overnight at 2.0 × 10 6 cells/…

[HTML][HTML] Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro

Y Tanaka, T Nakazawa, M Nakamura, F Nishimura… - PLoS …, 2019 - journals.plos.org
activating receptors of NK cells, such as NKG2D and DNAM-1, are expressed in GBM [12],
and the ligation of the activating … purity of NK cells but also prevented contamination with Tregs…

CD8αα expression on NK cells is associated with different K562 and MOLT4 killing capabilities of PBMC and different involvement CD8pos and CD8neg subsets in …

BV Dons'koi, EI Dubrovskyi - Likars' ka sprava, 2023 - liksprava.com
Ligation of CD8α on human natural killer cells prevents activation-induced apoptosis and
enhances cytolytic activity. Immunology, 116(3), 354– 361. https://doi.org/10.1111/j.1365-…